From Palladium to Bronsted Acid Catalysis: Highly Enantioselective Regiodivergent Addition of Alkoxyallenes to Pyrazolones | |
Department | 苏州研究院 |
Zhou H(周慧)1,2; Wei, Zhao1,2; Zhang JL(张金龙)1; Yang HM(杨化萌)1; Xia CG(夏春谷)1; Jiang GX(蒋高喜)1; Jiang GX(蒋高喜) | |
The second department | osso国家重点实验室 |
2017 | |
Source Publication | Angewandte Chemie International Edition |
ISSN | 1433-7851 |
Volume | 56Issue:4Pages:1077-1081 |
Abstract | A highly enantioselective regiodivergent addition of alkoxyallenes to pyrazolones was developed to afford multiply functionalized alkylated products bearing a quaternary carbon stereocenter in high yields with excellent stereoselectivities. One approach is enabled by palladium catalysis, thus leading to branched allylic pyrazol-5-ones under mild reaction conditions. The other is catalyzed by a chiral Brønsted acid to give linear products exclusively. Moreover, the usefulness of this new method was highlighted by converting the allylic products into other interesting multifunctionalized pyrazolone derivatives which would be of great potential for the exploitation of pharmaceutically important molecules. |
Keyword | Allenes Allylic Compounds Bronsted Acids Heterocycles Palladium |
Subject Area | 物理化学与绿色催化 |
DOI | 10.1002/anie.201610473 |
Funding Organization | Hundred Talent Program of Chinese Academy of Sciences (CAS);the National Natural Science Foundation of China (21202175;21602231);the Natural Science Foundation of Jiangsu (BK20160396) |
Indexed By | SCI |
If | 11.994 |
Language | 英语 |
Funding Project | 均相催化研究组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/21478 |
Collection | 苏州研究院 羰基合成与选择氧化国家重点实验室(OSSO) |
Corresponding Author | Jiang GX(蒋高喜) |
Affiliation | 1.Chinese Acad Sci, LICP, Suzhou Res Inst LICP, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
Recommended Citation GB/T 7714 | Zhou H,Wei, Zhao,Zhang JL,et al. From Palladium to Bronsted Acid Catalysis: Highly Enantioselective Regiodivergent Addition of Alkoxyallenes to Pyrazolones[J]. Angewandte Chemie International Edition,2017,56(4):1077-1081. |
APA | Zhou H.,Wei, Zhao.,Zhang JL.,Yang HM.,Xia CG.,...&蒋高喜.(2017).From Palladium to Bronsted Acid Catalysis: Highly Enantioselective Regiodivergent Addition of Alkoxyallenes to Pyrazolones.Angewandte Chemie International Edition,56(4),1077-1081. |
MLA | Zhou H,et al."From Palladium to Bronsted Acid Catalysis: Highly Enantioselective Regiodivergent Addition of Alkoxyallenes to Pyrazolones".Angewandte Chemie International Edition 56.4(2017):1077-1081. |
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Zhou_et_al-2017-Ange(908KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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