A Green Aerobic Oxidative Synthesis of Pyrrolo[1,2-a]quinoxalines from Simple Alcohols without Metals and Additives | |
Department | OSSO国家重点实验室 |
Li JX(李纪兴)1,2; Zhang JL(张金龙)1; Yang HM(杨化萌)1; Gao, Zeng1,2; Jiang GX(蒋高喜)1; Jiang GX(蒋高喜) | |
2017 | |
Source Publication | Journal of Organic Chemistry |
ISSN | 0022-3263 |
Volume | 82Issue:1Pages:765-769 |
Abstract | A practical and concise protocol for the efficient preparation of pyrrolo[1,2-a]quinoxalines through a cascade of alcohol oxidation/imine formation/intramolecular cyclization/oxidative dehydrogenation has been established. A series of substituted pyrrolo[1,2-a]quinoxaline derivatives were constructed readily in yields of 53–93% from the cheap primary alcohols by using dioxygen as the terminal oxidant. Remarkably, the fact that no extra metals and additives were necessary makes this unprecedented aerobic oxidation process highly step- and atom-economical. The usefulness of this transformation was further demonstrated with the gram-scale synthesis of compound 3aa under standard conditions. |
Subject Area | 物理化学与绿色催化 |
DOI | 10.1021/acs.joc.6b02501 |
Funding Organization | the Hundred Talents Program of Chinese Academy of Sciences (CAS);the Natural Science Foundation of Jiangsu (Grant No. BK20151235) |
Indexed By | SCI |
If | 4.849 |
Language | 英语 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/21291 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) 苏州研究院 |
Corresponding Author | Jiang GX(蒋高喜) |
Affiliation | 1.State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences, Lanzhou 730000, P. R. China 2.University of Chinese Academy of Sciences, Beijing 100049, P. R. China |
Recommended Citation GB/T 7714 | Li JX,Zhang JL,Yang HM,et al. A Green Aerobic Oxidative Synthesis of Pyrrolo[1,2-a]quinoxalines from Simple Alcohols without Metals and Additives[J]. Journal of Organic Chemistry,2017,82(1):765-769. |
APA | Li JX,Zhang JL,Yang HM,Gao, Zeng,Jiang GX,&蒋高喜.(2017).A Green Aerobic Oxidative Synthesis of Pyrrolo[1,2-a]quinoxalines from Simple Alcohols without Metals and Additives.Journal of Organic Chemistry,82(1),765-769. |
MLA | Li JX,et al."A Green Aerobic Oxidative Synthesis of Pyrrolo[1,2-a]quinoxalines from Simple Alcohols without Metals and Additives".Journal of Organic Chemistry 82.1(2017):765-769. |
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acs.joc.6b02501.pdf(728KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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