Preparation and characterization of a drug vehicle: Polymer brush immobilized Ag nanoparticles onto titanium nanotubes | |
Department | 固体润滑国家重点实验室 |
Zhang, Min1; Wei, Mouda1; Wang DA(王道爱)2; Duan, Yinzhong1; Wang DA(王道爱) | |
2014 | |
Source Publication | Materials Letters |
ISSN | 0167-577X |
Volume | 135Pages:51-54 |
Abstract | Bacterial infection has been identified as one of the major causes of titanium implant failures. In this study, a novel antibiotic vehicle composite, TiO2NT–PSPMA, was synthesized via atom transfer radical polymerization; this method improved the local antibiotic concentration and prolonged its sustainable release by loading larger amounts of antibiotic into titania nanotubes (TiO2 NTs) arrayed on Ti implants. Ag nanoparticles (NPs) were loaded into TiO2 NTs with the assistance of the ionic polymer 3-sulfopropyl methacrylate potassium salt (PSPMA). This composite increased the storage of Ag NPs by employing nanotubes and using PSPMA to trap larger amounts Ag NPs. The in vitro experiments showed that the composite had a dose-dependent cell proliferation by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), indicating that the composite has the potential to prevent the devastating consequences of implant infection. |
Keyword | Titania Nanotubes Polymers Microstructure Ag Nanoparticles Biomaterials |
Subject Area | 材料科学与物理化学 |
DOI | 10.1016/j.matlet.2014.07.138 |
Funding Organization | NSFC (21303227;21125316) |
Indexed By | SCI |
If | 2.489 |
Language | 英语 |
Funding Project | 材料表面与界面行为研究组 |
compositor | 第二作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/21266 |
Collection | 固体润滑国家重点实验室(LSL) |
Corresponding Author | Duan, Yinzhong; Wang DA(王道爱) |
Affiliation | 1.Fourth Mil Med Univ, Sch Stomatol, Dept Orthodont, Xian 710032, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China |
Recommended Citation GB/T 7714 | Zhang, Min,Wei, Mouda,Wang DA,et al. Preparation and characterization of a drug vehicle: Polymer brush immobilized Ag nanoparticles onto titanium nanotubes[J]. Materials Letters,2014,135:51-54. |
APA | Zhang, Min,Wei, Mouda,Wang DA,Duan, Yinzhong,&王道爱.(2014).Preparation and characterization of a drug vehicle: Polymer brush immobilized Ag nanoparticles onto titanium nanotubes.Materials Letters,135,51-54. |
MLA | Zhang, Min,et al."Preparation and characterization of a drug vehicle: Polymer brush immobilized Ag nanoparticles onto titanium nanotubes".Materials Letters 135(2014):51-54. |
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1-s2.0-S0167577X1401(1575KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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