| Enantioselective Total Synthesis of (-)-Walsucochin B | |
| Department | OSSO国家重点实验室 |
| Xu, Shiyan1; Gu, Jixiang1; Li HL(李辉林)1; Ma, Donghui1; Xie XG(谢新刚)1; She XG(厍学功)1,2; Xie XG(谢新刚); She XG(厍学功) | |
| 2014 | |
| Source Publication | Organic Letters
 |
| ISSN | 1523-7060 |
| Volume | 16Issue:7Pages:1996-1999 |
| Abstract | The first enantioselective total synthesis of the structurally unique nortriterpenoid (−)-walsucochin B has been accomplished through the cationic polyolefin cyclization initiated by chiral epoxide. The core framework and the stereocenters in the natural product were all constructed in this step. A site-selective, late-stage free-radical halogenation and Seyferth–Gilbert homologation was adopted to install the acetylene moiety to synthesize the phenylacetylene. The absolute configuration of walsucochin B was confirmed through enantioselective total synthesis. |
| Subject Area | 物理化学与绿色催化 |
| DOI | 10.1021/ol500553x |
| Funding Organization | the NSFC (21125207;21102062;21372103);the MOST (2010CB833203);PCSIRT (IRT1138);the FRFCU (lzujbky-2013-49;lzujbky-2013-ct02);Program 111 |
| Indexed By | SCI |
| If | 6.364 |
| Language | 英语 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/21250 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Xie XG(谢新刚); She XG(厍学功) |
| Affiliation | 1.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Xu, Shiyan,Gu, Jixiang,Li HL,et al. Enantioselective Total Synthesis of (-)-Walsucochin B[J]. Organic Letters,2014,16(7):1996-1999. |
| APA | Xu, Shiyan.,Gu, Jixiang.,Li HL.,Ma, Donghui.,Xie XG.,...&厍学功.(2014).Enantioselective Total Synthesis of (-)-Walsucochin B.Organic Letters,16(7),1996-1999. |
| MLA | Xu, Shiyan,et al."Enantioselective Total Synthesis of (-)-Walsucochin B".Organic Letters 16.7(2014):1996-1999. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| ol500553x.pdf（672KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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