Isocorydine Derivatives and Their Anticancer Activities

doi:10.3390/molecules190812099

LICP OpenIR > 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室

	Isocorydine Derivatives and Their Anticancer Activities
Department	中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
	Zhong M(钟梅)1,2; Liu YJ(刘言娟)1,2 ; Liu JX(柳军玺)1 ; Di DL(邸多隆)1 ; Xu, Mengrou 3; Yang, Yaya 3; Li, Wenguang 3; Chen, Yali 3; Liu, Jinxia 4; Liu JX(柳军玺)
	2014
Source Publication	Molecules
ISSN	1420-3049
Volume	19 Issue:8 Pages:12099-12115
Abstract	In order to improve the anticancer activity of isocorydine (ICD), ten isocorydine derivatives were prepared through chemical structure modifications, and their in vitro and in vivo activities were experimentally investigated. 8-Amino-isocorydine (8) and 6a,7-dihydrogen-isocorydione (10) could inhibit the growth of human lung (A549), gastric (SGC7901) and liver (HepG2) cancer cell lines in vitro. Isocorydione (2) could inhibit the tumor growth of murine sarcoma S₁₈₀-bearing mice, and 8-acetamino-isocorydine (11), a pro-drug of 8-amino-isocorydine (8), which is instable in water solution at room temperature, had a good inhibitory effect on murine hepatoma H₂₂-induced tumors. The results suggested that the isocorydine structural modifications at C-8 could significantly improve the biological activity of this alkaloid, indicating its suitability as a lead compound in the development of an effective anticancer agent.
Keyword	Aporphine Alkaloids Isocorydine Synthesis Anticancer Activity
Subject Area	分析化学与药物化学
DOI	10.3390/molecules190812099
Funding Organization	"West Light Program";"Build coalitions of the national academy of sciences" of Chinese Academy of Sciences;the science and technology program of Gansu (1304FKCA062)
Indexed By	SCI
If	2.416
Language	英语
Funding Project	药物工艺标准研究组
compositor	第一作者单位
Citation statistics	Cited Times:23[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.licp.cn/handle/362003/21231
Collection	中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
Corresponding Author	Liu JX(柳军玺)
Affiliation	1.Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China 2.Graduate University of the Chinese Academy of Sciences, Beijing 100049, China 3.Gansu Key Laboratory of Preclinical Study for New Drugs, Institute of Pharmacology, School of Basic Medical Science, Lanzhou University, Lanzhou 730000, China 4.Institute of Biology, Gansu Academy of Sciences, Lanzhou 730000, China
Recommended Citation GB/T 7714	Zhong M,Liu YJ,Liu JX,et al. Isocorydine Derivatives and Their Anticancer Activities[J]. Molecules,2014,19(8):12099-12115.
APA	Zhong M.,Liu YJ.,Liu JX.,Di DL.,Xu, Mengrou.,...&柳军玺.(2014).Isocorydine Derivatives and Their Anticancer Activities.Molecules,19(8),12099-12115.
MLA	Zhong M,et al."Isocorydine Derivatives and Their Anticancer Activities".Molecules 19.8(2014):12099-12115.

Files in This Item:
File Name/Size	DocType	Version	Access	License
molecules-19-12099-v（1271KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Application Full Text

File name:	molecules-19-12099-v2.pdf
Format:	Adobe PDF

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Institution:
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh

中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室知识库