Palladium-Catalyzed Aminomethylamination and Aromatization of Aminoalkenes with Aminals via C-N Bond Activation | |
Department | OSSO国家重点实验室 |
Li, Lixin1,3; Liu, Peipei1; Su YJ(苏毅进)1; Huang HM(黄汉民)1,2; Huang HM(黄汉民) | |
2016 | |
Source Publication | Organic Letters |
ISSN | 1523-7060 |
Volume | 18Issue:21Pages:5736-5739 |
Abstract | Thanks to the facile imine-enamine tautomerization, the β,γ-unsaturated hydrazones have been successfully utilized as surrogates of aminodienes for realizing the Pd-catalyzed tandem aminomethylamination/aromatization reaction with aminals via C–N bond activation. This direct and operationally simple protocol provides a fundamentally novel strategy to synthesize aromatic heterocycles from alkenes in the absence of external oxidant and base. Mechanistic studies suggested that aminal not only functioned as an aminomethyl source but also acted as formal oxidant and inner base to promote the aromatization. |
Subject Area | 物理化学与绿色催化 |
DOI | 10.1021/acs.orglett.6b03001 |
Funding Organization | the CAS Interdisciplinary Innovation Team;the National Natural Science Foundation of China (21133011;21672199) |
Indexed By | SCI |
If | 6.579 |
Language | 英语 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/21193 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) |
Corresponding Author | Huang HM(黄汉民) |
Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China 2.Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
Recommended Citation GB/T 7714 | Li, Lixin,Liu, Peipei,Su YJ,et al. Palladium-Catalyzed Aminomethylamination and Aromatization of Aminoalkenes with Aminals via C-N Bond Activation[J]. Organic Letters,2016,18(21):5736-5739. |
APA | Li, Lixin,Liu, Peipei,Su YJ,Huang HM,&黄汉民.(2016).Palladium-Catalyzed Aminomethylamination and Aromatization of Aminoalkenes with Aminals via C-N Bond Activation.Organic Letters,18(21),5736-5739. |
MLA | Li, Lixin,et al."Palladium-Catalyzed Aminomethylamination and Aromatization of Aminoalkenes with Aminals via C-N Bond Activation".Organic Letters 18.21(2016):5736-5739. |
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