Palladium-Catalyzed Intramolecular Hydroaminocarbonylation to Lactams: Additive-Free Protocol Initiated by Palladium Hydride | |
Department | OSSO国家重点实验室 |
Hu, Yue1,3; Shen ZQ(沈志强)1; Huang HM(黄汉民)1,2; Huang HM(黄汉民) | |
2016 | |
Source Publication | ACS Catalysis |
ISSN | 2155-5435 |
Volume | 6Issue:10Pages:6785-6789 |
Abstract | A palladium-catalyzed intramolecular hydroaminocarbonylation of 2-vinylbenzylamines in the absence of acidic or any other additives was realized via rational designing the catalytic system on the basis of mechanistic studies, which allows for the synthesis of a variety of six-membered lactams in good to excellent yields with high regioselectivity. The postulated palladium-hydride intermediate for initiating the hydroaminocarbonylation has been identified and directly used as a catalyst for the reaction. Further kinetic studies illustrated that the reaction rate is negative first-order-dependent on the substrate concentration with palladium hydride as a catalyst. |
Keyword | Intramolecular Hydroaminocarbonylation Palladium Hydride Aliphatic Amine Lactam Homogeneous Catalysis |
Subject Area | 物理化学与绿色催化 |
DOI | 10.1021/acscatal.6b01939 |
Funding Organization | the CAS Interdisciplinary Innovation Team;the National Natural Science Foundation of China (Nos. 21133011;21672199) |
Indexed By | SCI |
If | 10.614 |
Language | 英语 |
Funding Project | 有机功能材料研究组;日常管理与大型仪器组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/21034 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) |
Corresponding Author | Huang HM(黄汉民) |
Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China 2.Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
Recommended Citation GB/T 7714 | Hu, Yue,Shen ZQ,Huang HM,et al. Palladium-Catalyzed Intramolecular Hydroaminocarbonylation to Lactams: Additive-Free Protocol Initiated by Palladium Hydride[J]. ACS Catalysis,2016,6(10):6785-6789. |
APA | Hu, Yue,Shen ZQ,Huang HM,&黄汉民.(2016).Palladium-Catalyzed Intramolecular Hydroaminocarbonylation to Lactams: Additive-Free Protocol Initiated by Palladium Hydride.ACS Catalysis,6(10),6785-6789. |
MLA | Hu, Yue,et al."Palladium-Catalyzed Intramolecular Hydroaminocarbonylation to Lactams: Additive-Free Protocol Initiated by Palladium Hydride".ACS Catalysis 6.10(2016):6785-6789. |
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acscatal.6b01939.pdf(668KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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