| Preparation and evaluation of 2-methylimidazolium-functionalized silica as a mixed-mode stationary phase for hydrophilic interaction and anion-exchange chromatography | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Yang BB(杨贝贝)1,2; Liu HM(刘后梅)2; Chen J(陈佳)2 ; Guan M(关明)1; Qiu HD(邱洪灯)1,2; Guan M(关明); Qiu HD(邱洪灯)
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| 2016 | |
| Source Publication | Journal of Chromatography A
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| ISSN | 0021-9673 |
| Volume | 1468Pages:79-85 |
| Abstract | In this paper, a novel 2-methylimidazolium-functionalized silica stationary phase was prepared and further used for hydrophilic interaction and anion-exchange mixed-mode chromatography. The stationary phase was characterized by elemental analysis and Fourier transform infrared spectrometry. The chromatographic properties of this stationary phase were investigated by hydrophilic chromatography for the separation of nucleosides, nucleobases, water soluble vitamins, sulfonamides and saccharides, and ion chromatography for the separation of inorganic anions. The effect of acetonitrile content, salt concentration and pH values of the mobile phase on the retention of the stationary phases was also investigated. Compared with 1-methylimidazolium-functionalized silica stationary phase, this new stationary phase demonstrated similar or better separation selectivity. This new column demonstrated good performance and separation selectivity even better than a commercial hydrophilic column. Besides, 2-methylimidazolium-functionalized silica is possible to be modified again and used as a precursor to derivate some new stationary phases from the 3-position nitrogen. |
| Keyword | Stationary Phase 2-methylimidazolium-functionalized Silica Mixed-mode Separation Hydrophilic Interaction Liquid Chromatography Ion Exchange Chromatography |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1016/j.chroma.2016.09.021 |
| Funding Organization | the “Hundred Talents Program” of Chinese Academy of Sciences;the National Natural Science Foundation of China (21465023;21475142;21611140105);the funds for Distinguished Young Scientists of Gansu (1506RJDA281) |
| Indexed By | SCI |
| If | 3.981 |
| Language | 英语 |
| Funding Project | 药物分离材料研究组 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/20598 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Guan M(关明); Qiu HD(邱洪灯) |
| Affiliation | 1.Laboratory on Pollution Monitoring and Control, College of Chemistry and Chemical Engineering, Xinjiang Normal University, Urumqi, 830054, China 2.Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China |
| Recommended Citation GB/T 7714 | Yang BB,Liu HM,Chen J,et al. Preparation and evaluation of 2-methylimidazolium-functionalized silica as a mixed-mode stationary phase for hydrophilic interaction and anion-exchange chromatography[J]. Journal of Chromatography A,2016,1468:79-85. |
| APA | Yang BB.,Liu HM.,Chen J.,Guan M.,Qiu HD.,...&邱洪灯.(2016).Preparation and evaluation of 2-methylimidazolium-functionalized silica as a mixed-mode stationary phase for hydrophilic interaction and anion-exchange chromatography.Journal of Chromatography A,1468,79-85. |
| MLA | Yang BB,et al."Preparation and evaluation of 2-methylimidazolium-functionalized silica as a mixed-mode stationary phase for hydrophilic interaction and anion-exchange chromatography".Journal of Chromatography A 1468(2016):79-85. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 2016-JCA-Yang.pdf（1589KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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