| Synthesis of Benzofurans from Ketones and 1,4-Benzoquinones | |
| Department | OSSO国家重点实验室 |
| Wu, Fengtian1; Bai RX(白荣献)1; Gu YL(顾彦龙)1,2; Bai RX(白荣献); Gu YL(顾彦龙) | |
| 2016 | |
| Source Publication | Advanced Synthesis and Catalysis
 |
| ISSN | 1615-4150 |
| Volume | 358Issue:14Pages:2307-2316 |
| Abstract | Benzofuran derivatives can be synthesized through the sequential Michael addition and cyclization of 1,3-dicarbonyl compounds with 1,4-benzoquinones. However, ketones are rarely used in this reaction because of their low nucleophilicities. In this study, this problem was solved by utilizing triethyl orthoformate, which enabled the formation of a vinyl ethyl ether as an additive. As a result, the nucleophilicity of ketones increased. Many important 5-hydroxybenzofuran derivatives, which were not readily available by synthesis in the past, were also prepared via these newly established reactions. |
| Keyword | Benzofuran Benzoqunione Ketone Michael Addition Triethyl Orthoformate |
| Subject Area | 物理化学与绿色催化 |
| DOI | 10.1002/adsc.201600048 |
| Funding Organization | the National Natural Science Foundation of China (21373093);the Fundamental Research Funds for the Central Universities of China (2016YXZD033) |
| Indexed By | SCI |
| If | 5.646 |
| Language | 英语 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/20466 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Bai RX(白荣献); Gu YL(顾彦龙) |
| Affiliation | 1.Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Mat Chem Energy Convers & Storage, Minist Educ, Wuhan 430074, Peoples R China 2.Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Wu, Fengtian,Bai RX,Gu YL,et al. Synthesis of Benzofurans from Ketones and 1,4-Benzoquinones[J]. Advanced Synthesis and Catalysis,2016,358(14):2307-2316. |
| APA | Wu, Fengtian,Bai RX,Gu YL,白荣献,&顾彦龙.(2016).Synthesis of Benzofurans from Ketones and 1,4-Benzoquinones.Advanced Synthesis and Catalysis,358(14),2307-2316. |
| MLA | Wu, Fengtian,et al."Synthesis of Benzofurans from Ketones and 1,4-Benzoquinones".Advanced Synthesis and Catalysis 358.14(2016):2307-2316. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| LZ01029332.pdf（594KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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