| Metal-Free Synthesis of ortho-CHO Diaryl Ethers by a Three-Component Sequential Coupling | |
| Department | OSSO国家重点实验室 |
| Liu, Fangliang1; Yang HM(杨化萌)2; Hu XQ(胡信全)1,2; Jiang GX(蒋高喜)2,3; Jiang GX(蒋高喜) | |
| 2014 | |
| Source Publication | Organic Letters
 |
| ISSN | 1523-7060 |
| Volume | 16Issue:24Pages:6408-6411 |
| Abstract | A practical, metal-free, and highly chemoselective approach was developed for the synthesis of ortho-CHO diaryl ethers by a three-component sequential coupling of arynes, N,N-dimethylformamide (DMF), and diaryliodonium salts. Diverse functional groups including halo, nitryl, and bulky substituents and heteroaromatics are well tolerated. Mechanistically, isotopic tracer experiments reveal that the diaryliodonium salt serves as an electrophile to trap the transient intermediates generated from the [2 + 2] cyclization of an aryne and DMF. |
| Subject Area | 物理化学与绿色催化 |
| DOI | 10.1021/ol503224u |
| Funding Organization | Hundred Talent Program of Chinese Academy of Sciences (CAS) |
| Indexed By | SCI |
| If | 6.364 |
| Language | 英语 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/20331 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Jiang GX(蒋高喜) |
| Affiliation | 1.Zhejiang Univ Technol, Coll Chem Engn & Mat Sci, Hangzhou 310014, Zhejiang, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, Suzhou 215123, Peoples R China |
| Recommended Citation GB/T 7714 | Liu, Fangliang,Yang HM,Hu XQ,et al. Metal-Free Synthesis of ortho-CHO Diaryl Ethers by a Three-Component Sequential Coupling[J]. Organic Letters,2014,16(24):6408-6411. |
| APA | Liu, Fangliang,Yang HM,Hu XQ,Jiang GX,&蒋高喜.(2014).Metal-Free Synthesis of ortho-CHO Diaryl Ethers by a Three-Component Sequential Coupling.Organic Letters,16(24),6408-6411. |
| MLA | Liu, Fangliang,et al."Metal-Free Synthesis of ortho-CHO Diaryl Ethers by a Three-Component Sequential Coupling".Organic Letters 16.24(2014):6408-6411. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| ol503224u.pdf（626KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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