| Asymmetric Synthesis of CF3- and Indole-Containing Thiochromanes via a Squaramide-Catalyzed Michael-Aldol Reaction | |
| Department | OSSO国家重点实验室 |
Zhu, Yuanyuan1; Dong, Zhenghao1; Cheng, Xin1; Zhong, Xiaoling1; Liu, Xiaolin1; Lin, Li1; Shen ZQ(沈志强)2 ; Yang PJ(杨培菊)2; Li, Yuan3; Wang, Hailin3; Yan, Wenjin1; Wang, Kairong1; Wang R(王锐)1,2; Wang R(王锐)
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| 2016 | |
| Source Publication | Organic Letters
 |
| ISSN | 1523-7060 |
| Volume | 18Issue:15Pages:3546-3549 |
| Abstract | A Michael–aldol reaction of 2-mercaptobenzaldehyde with β-indole-β-CF3 enones catalyzed by a squaramide has been realized. The method affords a series of 2-CF3-2-indole-substituted thiochromanes featuring a CF3-containing quaternary stereocenter in excellent yields, diastereoselectivities, and enantioselectivities. |
| Subject Area | 物理化学与绿色催化 |
| DOI | 10.1021/acs.orglett.6b01498 |
| Funding Organization | the National Natural Science Foundation of China (21432003;21272107;21272108;81260387;81360112;81573265);the Fundamental Research Funds for the Central Universities (lzujbky-2015-155;lzujbky-2015-279) |
| Indexed By | SCI |
| If | 6.579 |
| Language | 英语 |
| Funding Project | 日常管理与大型仪器组 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/20308 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Yan, Wenjin; Wang, Kairong; Wang R(王锐) |
| Affiliation | 1.Lanzhou Univ, Inst Pharmacol, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic,Med Sci, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China 3.Peoples Hosp Gansu Prov, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Zhu, Yuanyuan,Dong, Zhenghao,Cheng, Xin,et al. Asymmetric Synthesis of CF3- and Indole-Containing Thiochromanes via a Squaramide-Catalyzed Michael-Aldol Reaction[J]. Organic Letters,2016,18(15):3546-3549. |
| APA | Zhu, Yuanyuan.,Dong, Zhenghao.,Cheng, Xin.,Zhong, Xiaoling.,Liu, Xiaolin.,...&王锐.(2016).Asymmetric Synthesis of CF3- and Indole-Containing Thiochromanes via a Squaramide-Catalyzed Michael-Aldol Reaction.Organic Letters,18(15),3546-3549. |
| MLA | Zhu, Yuanyuan,et al."Asymmetric Synthesis of CF3- and Indole-Containing Thiochromanes via a Squaramide-Catalyzed Michael-Aldol Reaction".Organic Letters 18.15(2016):3546-3549. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| acs.orglett.6b01498.（575KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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