| Expedient Synthesis of Chiral alpha-Amino Acids through Nickel-Catalyzed Reductive Cross-Coupling | |
| Department | OSSO国家重点实验室 |
| Lu, Xi1,2,3; Yi, Jun1; Zhang, Zhen-Qi1; Dai, Jian-Jun1; Liu, Jing-Hui1; Xiao, Bin1; Fu, Yao1; Liu, Lei1,2,3 | |
| 2014 | |
| Source Publication | Chemistry - A European Journal
 |
| ISSN | 0947-6539 |
| Volume | 20Issue:47Pages:15339-15343 |
| Abstract | A novel method for the synthesis of non-natural L- and D-amino acids by a Ni-catalyzed reductive cross-coupling reaction is described. This strategy enables the racemization-free cross-coupling of serine/homoserine-derived iodides with aryl/acyl/alkyl halides. It provides convenient access to varieties of enantiopure and functionalized amino acids, which are important building blocks in bioactive compounds and pharmaceuticals. |
| Keyword | Amino Acids Catalysis C-c Bond Formation Nickel Reductive Cross-coupling |
| Subject Area | 物理化学与绿色催化 |
| DOI | 10.1002/chem.201405296 |
| Funding Organization | the "863" Program of the Ministry of Science and Technology (2012AA02A700);the National Basic Research Program of China (973 program, No. 2013CB932800);NSFC (Nos. 21472181;91313301;21221062);SRFDP (20133402120034) |
| Indexed By | SCI |
| If | 5.731 |
| Language | 英语 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/20286 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Xiao, Bin; Liu, Lei |
| Affiliation | 1.Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China 3.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China |
| Recommended Citation GB/T 7714 | Lu, Xi,Yi, Jun,Zhang, Zhen-Qi,et al. Expedient Synthesis of Chiral alpha-Amino Acids through Nickel-Catalyzed Reductive Cross-Coupling[J]. Chemistry - A European Journal,2014,20(47):15339-15343. |
| APA | Lu, Xi.,Yi, Jun.,Zhang, Zhen-Qi.,Dai, Jian-Jun.,Liu, Jing-Hui.,...&Liu, Lei.(2014).Expedient Synthesis of Chiral alpha-Amino Acids through Nickel-Catalyzed Reductive Cross-Coupling.Chemistry - A European Journal,20(47),15339-15343. |
| MLA | Lu, Xi,et al."Expedient Synthesis of Chiral alpha-Amino Acids through Nickel-Catalyzed Reductive Cross-Coupling".Chemistry - A European Journal 20.47(2014):15339-15343. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Lu_et_al-2014-Chemis（513KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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