Water as Co-Hydrogen Donor in Reductive Aminations | |
Department | OSSO国家重点实验室 |
Ke ZG(柯振刚)1,2; Cui XJ(崔新江)1; Shi F(石峰)1; Shi F(石峰) | |
2016 | |
Source Publication | ACS Sustainable Chemistry and Engineering |
ISSN | 2168-0485 |
Volume | 4Issue:7Pages:3921-3926 |
Abstract | Reductive amination generates an important reaction in fine chemical synthesis. The employment of water as the hydrogen donor for reductive amination might solve the long-time hydrogen supply problem. Here, we present our new results on reductive N-methylation reactions of amine with paraformaldehyde with water as the co-hydrogen donor catalyzed by a simple supported nanogold catalyst, i.e., Au/Al2O3. N-Methyl amines or N,N-dimethyl amines can be selectively synthesized with excellent yields. Isotope tracing reactions confirmed the transformation of hydrogen from water in the final product. In addition, this method can be applied in the N-methylation reactions of bioactive molecules with excellent performance. This concept may supply a potential methodology for sustainable reductive amination. |
Keyword | Amine Formaldehyde N-methylation Water Reducing Agent Nanogold |
Subject Area | 物理化学与绿色催化 |
DOI | 10.1021/acssuschemeng.6b00764 |
Funding Organization | the National Natural Science Foundation of China (21303228);Youth Innovation Promotion Association CAS |
Indexed By | SCI |
If | 5.951 |
Language | 英语 |
Funding Project | 纳米催化课题组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/20245 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) 绿色化学研究发展中心 |
Corresponding Author | Shi F(石峰) |
Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Green Chem & Catalysis, State Key Lab Oxo Synth & Select Oxidat, 18 Tianshui Middle Rd, Lanzhou 730000, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquanlu, Beijing 100049, Peoples R China |
Recommended Citation GB/T 7714 | Ke ZG,Cui XJ,Shi F,et al. Water as Co-Hydrogen Donor in Reductive Aminations[J]. ACS Sustainable Chemistry and Engineering,2016,4(7):3921-3926. |
APA | Ke ZG,Cui XJ,Shi F,&石峰.(2016).Water as Co-Hydrogen Donor in Reductive Aminations.ACS Sustainable Chemistry and Engineering,4(7),3921-3926. |
MLA | Ke ZG,et al."Water as Co-Hydrogen Donor in Reductive Aminations".ACS Sustainable Chemistry and Engineering 4.7(2016):3921-3926. |
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acssuschemeng.6b0076(642KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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