| New sesquiterpenes and benzofuran derivatives from the aerial parts of Asterothamnus centrali-asiaticus | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Wang YM(王衍明)1,4; Zhao, Jian-Qiang2,4; Zhou, Shuang-Yan3; Yang JL(杨军丽)1 ; Yao, Xiao-Jun3; Tao, Yan-Duo2; Mei, Li-Juan2; Shi YP(师彦平)1; Shi YP(师彦平)
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| 2016 | |
| Source Publication | Tetrahedron
 |
| ISSN | 0040-4020 |
| Volume | 72Issue:32Pages:4910-4917 |
| Abstract | Phytochemical investigation on Asterothamnus centrali-asiaticus afforded four new sesquiterpenes, asterothamnones A–D (1–4), and three new benzofuran derivatives (5–7) together with ten known compounds (8–17). Their structures were elucidated using 1D and 2D NMR and X-ray diffraction analyses. Compounds 1–4 were verified to be unusual eudesmane sesquiterpenes possessing 4,6-dien-3-one or 1,4,6-triene-3-one conjugated system. The absolute configurations of compounds 1–8 were established by means of calculated electronic circular dichroism (ECD). Furthermore, all isolates were evaluated for their cytotoxic and anti-oxidant activities. Results showed that 10, 12 and, 14 exhibited cytotoxic activity against HepG2 cancer cells and 14 displayed cytotoxicity against MGC-803 cancer cells. Compounds 10 and 17 showed anti-oxidant effect. |
| Keyword | Asterothamnus Centrali-asiaticus Sesquiterpenes Asterothamnones Benzofuran Derivatives |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1016/j.tet.2016.06.061 |
| Funding Organization | the National Nature Science Foundation of China (Nos. 21375136;21575150);the scientific research project of Central Asia Drug Discovery and Development Centre of Chinese Academy of Sciences (No. CAM201404);the CAS Pioneer Hundred Talents Program |
| Indexed By | SCI |
| If | 2.651 |
| Language | 英语 |
| Funding Project | 药物化学成分研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/20243 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Shi YP(师彦平) |
| Affiliation | 1.Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China 2.Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, PR China 3.State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China 4.University of Chinese Academy of Sciences, 100049, Beijing, PR China |
| Recommended Citation GB/T 7714 | Wang YM,Zhao, Jian-Qiang,Zhou, Shuang-Yan,et al. New sesquiterpenes and benzofuran derivatives from the aerial parts of Asterothamnus centrali-asiaticus[J]. Tetrahedron,2016,72(32):4910-4917. |
| APA | Wang YM.,Zhao, Jian-Qiang.,Zhou, Shuang-Yan.,Yang JL.,Yao, Xiao-Jun.,...&师彦平.(2016).New sesquiterpenes and benzofuran derivatives from the aerial parts of Asterothamnus centrali-asiaticus.Tetrahedron,72(32),4910-4917. |
| MLA | Wang YM,et al."New sesquiterpenes and benzofuran derivatives from the aerial parts of Asterothamnus centrali-asiaticus".Tetrahedron 72.32(2016):4910-4917. |
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| File Name/Size | DocType | Version | Access | License | ||
| 1-s2.0-S004040201630（1447KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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