Nanocellulose Derivative/Silica Hybrid Core-Shell Chiral Stationary Phase: Preparation and Enantioseparation Performance | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Zhang XL(张晓莉)1,2,3; Wang LT(王利涛)1,2; Dong SQ(董树清)1,2; Zhang X(张霞)1,2; Wu Q(武琪)1,2,3; Zhao L(赵亮)1,2; Shi YP(师彦平)1,2; Zhao L(赵亮); Shi YP(师彦平) | |
2016 | |
Source Publication | Molecules |
ISSN | 1420-3049 |
Volume | 21Issue:5Pages:561(1-14) |
Abstract | Core-shell silica microspheres with a nanocellulose derivative in the hybrid shell were successfully prepared as a chiral stationary phase by a layer-by-layer self-assembly method. The hybrid shell assembled on the silica core was formed using a surfactant as template by the copolymerization reaction of tetraethyl orthosilicate and the nanocellulose derivative bearing triethoxysilyl and 3,5-dimethylphenyl groups. The resulting nanocellulose hybrid core-shell chiral packing materials (CPMs) were characterized and packed into columns, and their enantioseparation performance was evaluated by high performance liquid chromatography. The results showed that CPMs exhibited uniform surface morphology and core-shell structures. Various types of chiral compounds were efficiently separated under normal and reversed phase mode. Moreover, chloroform and tetrahydrofuran as mobile phase additives could obviously improve the resolution during the chiral separation processes. CPMs still have good chiral separation property when eluted with solvent systems with a high content of tetrahydrofuran and chloroform, which proved the high solvent resistance of this new material. |
Keyword | Nanocrystalline Cellulose Chiral Stationary Phase Core-shell Material Enantioseparation High Performance Liquid Chromatography |
Subject Area | 分析化学与药物化学 |
DOI | 10.3390/molecules21050561 |
Funding Organization | the National Natural Science Foundation (Nos. 21405162;21405161;20675085);the Key Projects of Urumqi Science and Technology Bureau (Y141320007) |
Indexed By | SCI |
If | 2.861 |
Language | 英语 |
Funding Project | 药物手性分离研究组;药物化学成分研究组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/20221 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Zhao L(赵亮); Shi YP(师彦平) |
Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
Recommended Citation GB/T 7714 | Zhang XL,Wang LT,Dong SQ,et al. Nanocellulose Derivative/Silica Hybrid Core-Shell Chiral Stationary Phase: Preparation and Enantioseparation Performance[J]. Molecules,2016,21(5):561(1-14). |
APA | Zhang XL.,Wang LT.,Dong SQ.,Zhang X.,Wu Q.,...&师彦平.(2016).Nanocellulose Derivative/Silica Hybrid Core-Shell Chiral Stationary Phase: Preparation and Enantioseparation Performance.Molecules,21(5),561(1-14). |
MLA | Zhang XL,et al."Nanocellulose Derivative/Silica Hybrid Core-Shell Chiral Stationary Phase: Preparation and Enantioseparation Performance".Molecules 21.5(2016):561(1-14). |
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Molecules-张晓莉.pdf(4056KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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