Diastereoselective and Enantioselective Synthesis of Unsymmetric beta,beta-Diaryl-alpha-Amino Acid Esters via Organocatalytic 1,6-Conjugate Addition of para-Quinone Methides

doi:10.1021/acs.joc.6b00390

	Diastereoselective and Enantioselective Synthesis of Unsymmetric beta,beta-Diaryl-alpha-Amino Acid Esters via Organocatalytic 1,6-Conjugate Addition of para-Quinone Methides
Department	OSSO国家重点实验室
	Zhang, Xiang-Zhi 1; Deng, Yu-Hua 3; Yan, Xu 1; Yu, Ke-Yin 1; Wang, Fang-Xin 1; Ma, Xiao-Yan 1; Fan, Chun-An 1,2
	2016
Source Publication	Journal of Organic Chemistry
ISSN	0022-3263
Volume	81 Issue:13 Pages:5655-5662
Abstract	A novel strategy based on phase transfer catalysis for the diastereoselective and enantioselective direct assembly of unsymmetric beta,beta-diaryl-alpha-amino acid esters via 1,6-conjugate addition of para-quinone methides and glycine derivatives is described. This protocol also provides an alternative route to the synthetically interesting functionalized chiral tetrahydroisoquinoline and its analogues.
Subject Area	物理化学与绿色催化
DOI	10.1021/acs.joc.6b00390
Funding Organization	the National Natural Science Foundation of China (21572083;21322201;21290180);the Fundamental Research Funds for the Central Universities (lzujbky-2015-58);the State Key Laboratory of Natural and Biomimetic Drugs (K20150213);PCSIRT (IRT-15R28);the 111 Project of Ministry of Education of China (111-2-17);Chang Jiang Scholars Program (C.A.F.)
Indexed By	SCI
If	4.849
Language	英语
compositor	第三作者单位
Citation statistics	Cited Times:97[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.licp.cn/handle/362003/20197
Collection	羰基合成与选择氧化国家重点实验室（OSSO）
Affiliation	1.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, 222 Tianshui Nanlu, Lanzhou 730000, Peoples R China 2.Peking Univ, State Key Lab Nat & Biomimet Drugs, 38 Xueyuan Lu, Beijing 100191, Peoples R China 3.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China
Recommended Citation GB/T 7714	Zhang, Xiang-Zhi,Deng, Yu-Hua,Yan, Xu,et al. Diastereoselective and Enantioselective Synthesis of Unsymmetric beta,beta-Diaryl-alpha-Amino Acid Esters via Organocatalytic 1,6-Conjugate Addition of para-Quinone Methides[J]. Journal of Organic Chemistry,2016,81(13):5655-5662.
APA	Zhang, Xiang-Zhi.,Deng, Yu-Hua.,Yan, Xu.,Yu, Ke-Yin.,Wang, Fang-Xin.,...&Fan, Chun-An.(2016).Diastereoselective and Enantioselective Synthesis of Unsymmetric beta,beta-Diaryl-alpha-Amino Acid Esters via Organocatalytic 1,6-Conjugate Addition of para-Quinone Methides.Journal of Organic Chemistry,81(13),5655-5662.
MLA	Zhang, Xiang-Zhi,et al."Diastereoselective and Enantioselective Synthesis of Unsymmetric beta,beta-Diaryl-alpha-Amino Acid Esters via Organocatalytic 1,6-Conjugate Addition of para-Quinone Methides".Journal of Organic Chemistry 81.13(2016):5655-5662.

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