Ionic-liquid-based dispersive liquid-liquid microextraction coupled with high-performance liquid chromatography for the forensic determination of methamphetamine in human urine | |
Department | OSSO国家重点实验室 |
Wang RF(王瑞峰)1,2,3; Qi XJ(亓秀娟)1; Zhao, Lei3; Liu SM(刘士民)1; Gao, Shuang3; Ma XY(马祥元)1; Deng YQ(邓友全)1; Deng YQ(邓友全) | |
The second department | 固体润滑国家重点实验室 |
2016 | |
Source Publication | Journal of Separation Science |
ISSN | 1615-9306 |
Volume | 39Issue:13Pages:2444-2450 |
Abstract | Determination of methamphetamine in forensic laboratories is a major issue due to its health and social harm. In this work, a simple, sensitive, and environmentally friendly method based on ionic liquid dispersive liquid-liquid microextraction combined with high-performance liquid chromatography was established for the analysis of methamphetamine in human urine. 1-Octyl-3-methylimidazolium hexafluorophosphate with the help of disperser solvent methanol was selected as the microextraction solvent in this process. Various parameters affecting the extraction efficiency of methamphetamine were investigated systemically, including extraction solvent and its volume, disperser solvent and its volume, sample pH, extraction temperature, and centrifugal time. Under the optimized conditions, a good linearity was obtained in the concentration range of 10-1000 ng/mL with determination coefficient >0.99. The limit of detection calculated at a signal-to-noise ratio of 3 was 1.7 ng/mL and the relative standard deviations for six replicate experiments at three different concentration levels of 100, 500, and 1000 ng/mL were 6.4, 4.5, and 4.7%, respectively. Meanwhile, up to 220-fold enrichment factor of methamphetamine and acceptable extraction recovery (>80.0%) could be achieved. Furthermore, this method has been successfully employed for the sensitive detection of a urine sample from a suspected drug abuser. |
Keyword | Dispersive Liquid-liquid Microextraction Forensic Detection Ionic Liquids Methamphetamine |
Subject Area | 物理化学与绿色催化 |
DOI | 10.1002/jssc.201600170 |
Funding Organization | National Natural Science Foundation of China (No. 21305146;21403259) |
Indexed By | SCI |
If | 2.557 |
Language | 英语 |
Funding Project | 绿色催化课题组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/20191 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) 固体润滑国家重点实验室(LSL) |
Corresponding Author | Deng YQ(邓友全) |
Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Ctr Green Chem & Catalysis, Lanzhou, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Publ Secur Bur Ordos, Ordos, Inner Mongolia, Peoples R China |
Recommended Citation GB/T 7714 | Wang RF,Qi XJ,Zhao, Lei,et al. Ionic-liquid-based dispersive liquid-liquid microextraction coupled with high-performance liquid chromatography for the forensic determination of methamphetamine in human urine[J]. Journal of Separation Science,2016,39(13):2444-2450. |
APA | Wang RF.,Qi XJ.,Zhao, Lei.,Liu SM.,Gao, Shuang.,...&邓友全.(2016).Ionic-liquid-based dispersive liquid-liquid microextraction coupled with high-performance liquid chromatography for the forensic determination of methamphetamine in human urine.Journal of Separation Science,39(13),2444-2450. |
MLA | Wang RF,et al."Ionic-liquid-based dispersive liquid-liquid microextraction coupled with high-performance liquid chromatography for the forensic determination of methamphetamine in human urine".Journal of Separation Science 39.13(2016):2444-2450. |
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