Discovery of biomarkers for oxidative stress based on cellular metabolomics | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Wang, Ningli1,2,3,4; Wei JT(魏鉴腾)2,3,4; Liu, Yewei1; Pei D(裴栋)2,3,4; Hu, Qingping1; Wang, Yu1; Di DL(邸多隆)2,3,4; Wei JT(魏鉴腾) | |
The second department | 青岛研发中心/青岛市资源化学与新材料研究中心 |
2016 | |
Source Publication | Biomarkers |
ISSN | 1354-750X |
Volume | 21Issue:5Pages:449-457 |
Abstract | Oxidative stress has a close relationship with various pathologic physiology phenomena and the potential biomarkers of oxidative stress may provide evidence for clinical diagnosis or disease prevention. Metabolomics was employed to identify the potential biomarkers of oxidative stress. High-performance liquid chromatography–diode array detector, mass spectrometry and partial least squares discriminate analysis were used in this study. The 10, 15 and 13 metabolites were considered to discriminate the model group, vitamin E-treated group and l-glutathione-treated group, respectively. Some of them have been identified, namely, malic acid, vitamin C, reduced glutathione and tryptophan. Identification of other potential biomarkers should be conducted and their physiological significance also needs to be elaborated. |
Keyword | Biomarkers Metabolomics Oxidative Stress |
Subject Area | 分析化学与药物化学 |
DOI | 10.3109/1354750X.2016.1153720 |
Funding Organization | the National Natural Science Foundation of China (21175142;21505143);National High Technology Research and Development Program of China (2014AA022203);Science Foundation of Gansu Province (1308RJYA077) |
Indexed By | SCI |
If | 2.006 |
Language | 英语 |
Funding Project | 药物工艺标准研究组 |
compositor | 第二作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/20148 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 青岛研发中心/青岛市资源化学与新材料研究中心 |
Corresponding Author | Wang, Ningli; Wei JT(魏鉴腾) |
Affiliation | 1.Lanzhou Univ, Sch Publ Hlth, Inst Nutr & Food Hyg, 199 Donggang West Rd, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, 18 Tianshui Middle Rd, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, 18 Tianshui Middle Rd, Lanzhou 730000, Peoples R China 4.Ctr Resource Chem & New Mat, Qingdao, Peoples R China |
Recommended Citation GB/T 7714 | Wang, Ningli,Wei JT,Liu, Yewei,et al. Discovery of biomarkers for oxidative stress based on cellular metabolomics[J]. Biomarkers,2016,21(5):449-457. |
APA | Wang, Ningli.,Wei JT.,Liu, Yewei.,Pei D.,Hu, Qingping.,...&魏鉴腾.(2016).Discovery of biomarkers for oxidative stress based on cellular metabolomics.Biomarkers,21(5),449-457. |
MLA | Wang, Ningli,et al."Discovery of biomarkers for oxidative stress based on cellular metabolomics".Biomarkers 21.5(2016):449-457. |
Files in This Item: | ||||||
File Name/Size | DocType | Version | Access | License | ||
LZ01029070.pdf(2155KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment