Nanocellulose 3, 5-Dimethylphenylcarbamate Derivative Coated Chiral Stationary Phase: Preparation and Enantioseparation Performance | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Zhang XL(张晓莉)1,2; Wang LT(王利涛)1; Dong SQ(董树清)1; Zhang X(张霞)1; Wu Q(武琪)1,2; Zhao L(赵亮)1; Shi YP(师彦平)1; Zhao L(赵亮); Shi YP(师彦平) | |
2016 | |
Source Publication | Chirality |
ISSN | 0899-0042 |
Volume | 28Issue:5Pages:376-381 |
Abstract | Nanocrystalline cellulose (NCC) with high surface area and high ordered crystalline structure was prepared from microcrystalline cellulose (MCC) under the hydrolysis of sodium hypochlorite. NCC was further reacted with 3,5-dimethylphenyl isocyanate to obtain the nanocellulose derivative, and then coated successfully on the surface of silica gel to a prepared NCC-coated chiral stationary phase (CSP) as a new kind of chiral separation material. Similarly, MCC derivative-coated CSP was also prepared as contrast. The chiral separation performance of NCC-based CSP was evaluated and compared with MCC-based CSP by high-performance liquid chromatography. Moreover, the effects of the alcohol modifiers, mobile phase additives, and flow rates on chiral separations were investigated in detail. The results showed that 10 chiral compounds were separated on NCC-based CSP with better peak shape and higher column efficiency than MCC-based CSP, which confirmed that NCC-based CSP was a promising packing material for the resolution of chiral compounds. |
Keyword | Nanocrystalline Cellulose Chiral Stationary Phases 3 Enantioseparation 5-dimethylphenylcarbamate High Performance Liquid Chromatography |
Subject Area | 分析化学与药物化学 |
DOI | 10.1002/chir.22578 |
Funding Organization | the National Natural Science Foundation (Nos. 21405162;21405161;20675085);the Key Projects of Urumqi Science and Technology Bureau (Y141320007) |
Indexed By | SCI |
If | 1.956 |
Language | 英语 |
Funding Project | 药物手性分离研究组;药物化学成分研究组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/20060 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Zhao L(赵亮); Shi YP(师彦平) |
Affiliation | 1.Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou, Gansu Province, P.R. China 2.University of Chinese Academy of Sciences, Beijing, P.R. China |
Recommended Citation GB/T 7714 | Zhang XL,Wang LT,Dong SQ,et al. Nanocellulose 3, 5-Dimethylphenylcarbamate Derivative Coated Chiral Stationary Phase: Preparation and Enantioseparation Performance[J]. Chirality,2016,28(5):376-381. |
APA | Zhang XL.,Wang LT.,Dong SQ.,Zhang X.,Wu Q.,...&师彦平.(2016).Nanocellulose 3, 5-Dimethylphenylcarbamate Derivative Coated Chiral Stationary Phase: Preparation and Enantioseparation Performance.Chirality,28(5),376-381. |
MLA | Zhang XL,et al."Nanocellulose 3, 5-Dimethylphenylcarbamate Derivative Coated Chiral Stationary Phase: Preparation and Enantioseparation Performance".Chirality 28.5(2016):376-381. |
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