Facile synthesis of 3,4-fused tricyclic indoles with a seven-membered ring through a three-component reaction of 4-hydroxyindole, aldehyde, and malonodinitrile or ethyl cyanoacetate

doi:10.1016/j.tet.2016.03.014

	Facile synthesis of 3,4-fused tricyclic indoles with a seven-membered ring through a three-component reaction of 4-hydroxyindole, aldehyde, and malonodinitrile or ethyl cyanoacetate
Department	OSSO国家重点实验室
	Bai, Rongxian 1; Yang, Jian 1; Min, Lijun 1; Liu, Changhui 1; Wu, Fengtian 1; Gu YL(顾彦龙)1,2; Gu YL(顾彦龙)
	2016
Source Publication	Tetrahedron
ISSN	0040-4020
Volume	72 Issue:17 Pages:2170-2177
Abstract	Three-component reactions of 4-hydroxyindole, aldehydes, and malonodinitrile or ethyl cyanoacetate were developed for the first time by using either potassium fluoride or diethylamine as a catalyst, which provided an easy access to 3,4-fused tricyclic indoles in good to excellent yield. The merits of this synthesis route are attributed to its simplicity, practicality, efficiency, and eco-friendliness, as well as the easy availability of the catalyst.
Keyword	Three-component Reaction 4-hydroxyindole Seven-membered Heterocycle 3 4-fused Tricyclic Indole
Subject Area	物理化学与绿色催化
DOI	10.1016/j.tet.2016.03.014
Funding Organization	National Natural Science Foundation of China (21373093);the Fundamental Research Funds for the Central Universities of China (2014ZZGH019);Analytical and Testing Center of HUST;Chutian Scholar Program of the Hubei Provincial Government and the Cooperative Innovation Center of Hubei Province
Indexed By	SCI
If	2.651
Language	英语
compositor	第二作者单位
Citation statistics	Cited Times:7[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.licp.cn/handle/362003/20006
Collection	羰基合成与选择氧化国家重点实验室（OSSO）
Corresponding Author	Gu YL(顾彦龙)
Affiliation	1.Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Large Format Battery Mat & Syst, Minist Educ, Wuhan 430074, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China
Recommended Citation GB/T 7714	Bai, Rongxian,Yang, Jian,Min, Lijun,et al. Facile synthesis of 3,4-fused tricyclic indoles with a seven-membered ring through a three-component reaction of 4-hydroxyindole, aldehyde, and malonodinitrile or ethyl cyanoacetate[J]. Tetrahedron,2016,72(17):2170-2177.
APA	Bai, Rongxian.,Yang, Jian.,Min, Lijun.,Liu, Changhui.,Wu, Fengtian.,...&顾彦龙.(2016).Facile synthesis of 3,4-fused tricyclic indoles with a seven-membered ring through a three-component reaction of 4-hydroxyindole, aldehyde, and malonodinitrile or ethyl cyanoacetate.Tetrahedron,72(17),2170-2177.
MLA	Bai, Rongxian,et al."Facile synthesis of 3,4-fused tricyclic indoles with a seven-membered ring through a three-component reaction of 4-hydroxyindole, aldehyde, and malonodinitrile or ethyl cyanoacetate".Tetrahedron 72.17(2016):2170-2177.

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