| Isolation of Secondary Metabolites from the Soil-Derived Fungus Clonostachys rosea YRS-06, a Biological Control Agent, and Evaluation of Antibacterial Activity | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Zhai, Ming-Ming1; Qi, Feng-Ming1; Li, Jie1; Jiang, Chun-Xiao1; Hou, Yue1; Shi YP(师彦平)2 ; Di DL(邸多隆)2; Zhang, Ji-Wen3; Wu, Quan-Xiang1,2
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| 2016 | |
| Source Publication | Journal of Agricultural and Food Chemistry
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| ISSN | 0021-8561 |
| Volume | 64Issue:11Pages:2298-2306 |
| Abstract | The fungus Clonostachys rosea is widely distributed all over the world. The destructive force of this fungus, as a biological control agent, is very strong to lots of plant pathogenic fungi. As part of the ongoing search for antibiotics from fungi obtained from soil samples, the secondary metabolites of C. rosea YRS-06 were investigated. Through efficient bioassay-guided isolation, three new bisorbicillinoids possessing open-ended cage structures, tetrahydrotrichodimer ether (1) and dihydrotrichodimer ether A and B (2 and 3), and 12 known compounds were obtained. Their structures were determined via extensive NMR, HR-ESI-MS, and CD spectroscopic analyses and X-ray diffraction data. Compounds 1–3 are rare bisorbicillinoids with a γ-pyrone moiety. The biological properties of 1–15 were evaluated against six different Gram-positive and Gram-negative bacteria. Bisorbicillinoids, 2–5, and TMC-151 C and E, 14 and 15, showed potent antibacterial activity. |
| Keyword | Clonostachys Rosea Yrs-06 Antibacterial Activity Antifungal Activity Tetrahydrotrichodimer Ether Dihydrotrichodimer Ether Tmc-1s1 |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1021/acs.jafc.6b00556 |
| Funding Organization | the National Natural Science Foundation of China (No. 21202075;21272103);the 111 Project;the Scientific Research Foundation for Returned Overseas Students (No. 45);the Scientific Research Ability Training of Undergraduate Students Majoring in Chemistry by the Two Patters Based on the Tutorial System and Top Students Project (J1103307) |
| Indexed By | SCI |
| If | 3.154 |
| Language | 英语 |
| Funding Project | 药物化学成分研究组;药物工艺标准研究组 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/19989 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Wu, Quan-Xiang |
| Affiliation | 1.State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People’s Republic of China 2.Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, People’s Republic of China 3.Key Laboratory of Botanical Pesticide R&D in Shaanxi Province, Northwest A&F University, Yangling, Shaanxi 712100, People’s Republic of China |
| Recommended Citation GB/T 7714 | Zhai, Ming-Ming,Qi, Feng-Ming,Li, Jie,et al. Isolation of Secondary Metabolites from the Soil-Derived Fungus Clonostachys rosea YRS-06, a Biological Control Agent, and Evaluation of Antibacterial Activity[J]. Journal of Agricultural and Food Chemistry,2016,64(11):2298-2306. |
| APA | Zhai, Ming-Ming.,Qi, Feng-Ming.,Li, Jie.,Jiang, Chun-Xiao.,Hou, Yue.,...&Wu, Quan-Xiang.(2016).Isolation of Secondary Metabolites from the Soil-Derived Fungus Clonostachys rosea YRS-06, a Biological Control Agent, and Evaluation of Antibacterial Activity.Journal of Agricultural and Food Chemistry,64(11),2298-2306. |
| MLA | Zhai, Ming-Ming,et al."Isolation of Secondary Metabolites from the Soil-Derived Fungus Clonostachys rosea YRS-06, a Biological Control Agent, and Evaluation of Antibacterial Activity".Journal of Agricultural and Food Chemistry 64.11(2016):2298-2306. |
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| File Name/Size | DocType | Version | Access | License | ||
| acs.jafc.6b00556.pdf（1173KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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