Palladium-Catalyzed Regioselective Difluoroalkylation and Carbonylation of Alkynes | |
Department | 固体润滑国家重点实验室 |
Wang, Qang1; He, Yu-Tao1; Zhao, Jia-Hui1; Qiu, Yi-Feng1; Zheng, Lan1; Hu, Jing-Yuan1; Yang, Yu-Chen1; Liu XY(刘雪原)1; Liang YM(梁永民)1,2; Liang YM(梁永民) | |
2016 | |
Source Publication | Organic Letters |
ISSN | 1523-7060 |
Volume | 18Issue:11Pages:2664-2667 |
Abstract | A novel, four-component synthetic strategy to synthesize a series of β-difluoroalkyl unsaturated esters/amides with high regioslectivity is described. This Pd-catalyzed difluoroalkylation and carbonylation reaction can be carried out with simple starting materials. Through this protocol, two new C–C bonds (including one C–CF2 bond) and one C–O(N) bond are constructed simultaneously in a single step. The synthetic utility of this reaction system has been certified by the applicability to a wide scope of alkynes and nucleophiles. Preliminary mechanistic studies suggest that the difluoroalkyl radical pathway is involved in this reaction. |
Subject Area | 材料科学与物理化学 |
DOI | 10.1021/acs.orglett.6b01038 |
Funding Organization | the National Science Foundation (NSF21272101;NSF21472074;NSF21302076);the Program for Changjiang Scholars and Innovative Research Team in University (IRT1138;IRT15R28) |
Indexed By | SCI |
If | 6.579 |
Language | 英语 |
compositor | 第二作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/19978 |
Collection | 固体润滑国家重点实验室(LSL) |
Corresponding Author | Liang YM(梁永民) |
Affiliation | 1.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China |
Recommended Citation GB/T 7714 | Wang, Qang,He, Yu-Tao,Zhao, Jia-Hui,et al. Palladium-Catalyzed Regioselective Difluoroalkylation and Carbonylation of Alkynes[J]. Organic Letters,2016,18(11):2664-2667. |
APA | Wang, Qang.,He, Yu-Tao.,Zhao, Jia-Hui.,Qiu, Yi-Feng.,Zheng, Lan.,...&梁永民.(2016).Palladium-Catalyzed Regioselective Difluoroalkylation and Carbonylation of Alkynes.Organic Letters,18(11),2664-2667. |
MLA | Wang, Qang,et al."Palladium-Catalyzed Regioselective Difluoroalkylation and Carbonylation of Alkynes".Organic Letters 18.11(2016):2664-2667. |
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