| Synthesis of Chiral alpha-Trifluoromethylamines with 2,2,2-Trifluoroethylamine as a "Building Block" | |
| Department | OSSO国家重点实验室 |
Li, Xiaoyuan1; Su, Jinhuan1; Liu, Zhourujun1; Zhu, Yuanyuan1; Dong, Zhenghao1; Qiu, Shuai1; Wang, Jiayi1; Lin, Li1; Shen ZQ(沈志强)2 ; Yan, Wenjin1; Wang, Kairong1; Wang R(王锐)1,2,3; Wang R(王锐)
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| 2016 | |
| Source Publication | Organic Letters
 |
| ISSN | 1523-7060 |
| Volume | 18Issue:5Pages:956-959 |
| Abstract | The β-isocupreidine, a cinchonine derived alkaloid, catalyzed asymmetric SN2′–SN2′ reaction between N-2,2,2-trifluoroethylisatin ketimines and MBH type carbonates was realized in a simple and efficient way. A series of chiral α-trifluoromethylamines were prepared with excellent yields and stereoselectivities. A subsequent and easy process of deprotection gave γ-trifluoromethyl-α-methylenelactam in a stereoselective manner. |
| Subject Area | 物理化学与绿色催化 |
| DOI | 10.1021/acs.orglett.5b03566 |
| Funding Organization | the National Natural Science Foundation of China (Nos. 21432003;21272107;21272108;31200548;91213302;81573265) |
| Indexed By | SCI |
| If | 6.579 |
| Language | 英语 |
| Funding Project | 日常管理与大型仪器组 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/19775 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Yan, Wenjin; Wang, Kairong; Wang R(王锐) |
| Affiliation | 1.Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Inst Pharmacol, Sch Basic,Med Sci, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China 3.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China |
| Recommended Citation GB/T 7714 | Li, Xiaoyuan,Su, Jinhuan,Liu, Zhourujun,et al. Synthesis of Chiral alpha-Trifluoromethylamines with 2,2,2-Trifluoroethylamine as a "Building Block"[J]. Organic Letters,2016,18(5):956-959. |
| APA | Li, Xiaoyuan.,Su, Jinhuan.,Liu, Zhourujun.,Zhu, Yuanyuan.,Dong, Zhenghao.,...&王锐.(2016).Synthesis of Chiral alpha-Trifluoromethylamines with 2,2,2-Trifluoroethylamine as a "Building Block".Organic Letters,18(5),956-959. |
| MLA | Li, Xiaoyuan,et al."Synthesis of Chiral alpha-Trifluoromethylamines with 2,2,2-Trifluoroethylamine as a "Building Block"".Organic Letters 18.5(2016):956-959. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| acs.orglett.5b03566.（1018KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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