| Two new cembranic diterpenoids from the flowers of Nicotiana tabacum L. | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
He XF(何小凤)1,2; Hou, Xiao-Dong1; Ren X(任夏)2; Guo K(郭凯)2; Li XZ(李秀壮)2; Yan ZQ(燕志强)2 ; Du, Yong-Mei1; Zhang, Zhong-Feng1; Qin B(秦波)2
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| 2016 | |
| Source Publication | Phytochemistry Letters
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| ISSN | 1874-3900 |
| Volume | 15Pages:238-244 |
| Abstract | Two new cembranoids, together with fifteen known ones, were isolated from the flowers of Nicotiana tabacum L. The structures of the new compounds were established as (1βH,2E,4αOH,6αOH,7E,10αH,11αH,12βOH)-10,11-epoxy-2,7-cembradiene-4,6,12-triol (1) and (1βH,2E,4αOH,6αOH,7E,10βH,11βH,12αOH)-10,11-epoxy-2,7-cembradiene-4,6, 12-triol (2) by using spectroscopic analysis, including HRESIMS, IR, one- and two-dimensional NMR. A plausible biogenetic relationship of the isolated cembranoids was proposed. The antitumor activities of selected compounds against a panel of three human cancer HepG2, A549 and HCT-116 cell lines were evaluated by the MTT assay. Compound 5 exhibited moderate activity against Hep-G2 cell lines with an IC50 value of 14.38 μM. |
| Keyword | N. Tabacum Cembranic Diterpenoids Anti-tumor Activities |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1016/j.phytol.2016.02.006 |
| Funding Organization | Cooperation Program to Gansu Province of Lanzhou Branch of the Chinese Academy of Sciences;the Province-academy Cooperation Program of Henan Province of China (No. 102106000021) |
| Indexed By | SCI |
| If | 1.418 |
| Language | 英语 |
| Funding Project | 植物化学生态研究组 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/19771 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Affiliation | 1.Key Laboratory of Tobacco Diseases and Insect Pests Monitoring Controlling and Integrated Management, Institute of Tobacco Research, Chinese Academy of Agricultural Sciences, Qingdao 266101, China 2.Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China |
| Recommended Citation GB/T 7714 | He XF,Hou, Xiao-Dong,Ren X,et al. Two new cembranic diterpenoids from the flowers of Nicotiana tabacum L.[J]. Phytochemistry Letters,2016,15:238-244. |
| APA | He XF.,Hou, Xiao-Dong.,Ren X.,Guo K.,Li XZ.,...&Qin B.(2016).Two new cembranic diterpenoids from the flowers of Nicotiana tabacum L..Phytochemistry Letters,15,238-244. |
| MLA | He XF,et al."Two new cembranic diterpenoids from the flowers of Nicotiana tabacum L.".Phytochemistry Letters 15(2016):238-244. |
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| 1-s2.0-S187439001630（1057KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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