LICP OpenIR  > 固体润滑国家重点实验室(LSL)
Metal-Organic Frameworks/Graphene Oxide Composite: A New Enzymatic Immobilization Carrier for Hydrogen Peroxide Biosensors
Department固体润滑国家重点实验室
Fan ZJ(范增杰)1; Wang JQ(王金清)2; Nie, Yingying3; Ren, Liling1; Liu B(刘斌)1; Liu G(刘刚)2,4; Fan ZJ(范增杰); Liu B(刘斌)
2016
Source PublicationJournal of The Electrochemical Society
ISSN0013-4651
Volume163Issue:3Pages:B32-B37
Abstract

Enzymatic loss and inactivation are two main problems that can degrade the performance of biosensor. In order to resolve the problems, a new enzymatic immobilization carrier was developed by using biomimetic methods. Horseradish peroxidase (HRP) was initially encapsulated into zeolitic imidazolate frameworks (ZIFs) severed as protective structure. To overcome electron transfer barrier of ZIFs, graphene oxide (GO) of high conductive graphene precursor was used to enhance their conductivity. Subsequently, ZIFs@HRP/GO and GO-polyethyleneimine with opposite charges were alternatively assembled onto the substrate of indium tin oxide to construct multilayer films of the biosensor. Systematic characterizations showed that ZIF-8 with an average size of approximately 160.9 nm encapsulating HRP uniformly grew onto the surface of GO. The newly designed structure combined with the excellent properties of the GO and ZIFs guarantee easy, direct electrochemistry and good catalytic activity toward H2O2 oxidation can be achieved with this biosensor. Electrochemical experiment study indicate that the resulting biosensor presented a wide linear range of 0.02–6 mmol/L, a low detection limit of 3.4 μmol /L (S/N = 3), excellent anti-interference ability, and long-term stability as well.

Subject Area材料科学与物理化学
DOI10.1149/2.0531603jes
Funding Organizationthe Natural Science Foundation of China (81571829);the Fundamental Research Funds for Central Universities (lzujbky-2015-35;lzujbky-2015-289;lzujbky-2015-102);the Natural Science Foundation of Gansu Province, China (145RJZA126);the Science and Technology Projects of Gansu Province,China (145RJYA315);Youth Science and Technology Innovation Foundation of Gansu Academy of Sciences, China (2013 QN-02)
Indexed BySCI
If3.259
Language英语
Funding Project聚合物摩擦学组
compositor第二作者单位
Citation statistics
Cited Times:36[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.licp.cn/handle/362003/19745
Collection固体润滑国家重点实验室(LSL)
Corresponding AuthorFan ZJ(范增杰); Liu B(刘斌)
Affiliation1.Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Peoples R China
2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China
3.Gansu Acad Sci, Inst Sensing Technol, Lanzhou 730000, Peoples R China
4.Lanzhou Univ, Sch Informat Sci & Engn, Lanzhou 730000, Peoples R China
Recommended Citation
GB/T 7714
Fan ZJ,Wang JQ,Nie, Yingying,et al. Metal-Organic Frameworks/Graphene Oxide Composite: A New Enzymatic Immobilization Carrier for Hydrogen Peroxide Biosensors[J]. Journal of The Electrochemical Society,2016,163(3):B32-B37.
APA Fan ZJ.,Wang JQ.,Nie, Yingying.,Ren, Liling.,Liu B.,...&刘斌.(2016).Metal-Organic Frameworks/Graphene Oxide Composite: A New Enzymatic Immobilization Carrier for Hydrogen Peroxide Biosensors.Journal of The Electrochemical Society,163(3),B32-B37.
MLA Fan ZJ,et al."Metal-Organic Frameworks/Graphene Oxide Composite: A New Enzymatic Immobilization Carrier for Hydrogen Peroxide Biosensors".Journal of The Electrochemical Society 163.3(2016):B32-B37.
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