| Magnetic molecularly imprinted polymer for the detection of rhaponticin in Chinese patent medicines | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Chen FF(陈方方)1,2; Jie XY(解笑瑜)1,2; Shi YP(师彦平)1 ; Shi YP(师彦平)
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| 2012 | |
| Source Publication | Journal of Chromatography A
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| ISSN | 0021-9673 |
| Volume | 1252Pages:8-14 |
| Abstract | The magnetic molecularly imprinted polymers (MMIPs) had been synthesized for the selective extraction and clean-up of rhaponticin in Chinese patent medicines (CPM). The MMIPs were prepared via suspension polymerization, using Fe3O4 as magnetically component, rhaponticin as template molecule, acrylamide (AM) as functional monomers, styrene (St) as copolymer monomer and ethylene glycol dimethacrylate (EGDMA) as a cross-linker in dimethyl sulfoxide porogen. The obtained MMIPs were characterized using scanning electron microscopy (SEM) and Fourier transform infrared (FT-IR), X-ray diffraction (XRD) and vibrating sample magnetometer (VSM). High performance liquid chromatography (HPLC) was used for analysis the target analytes. The polymers were evaluated further by batch rebinding experiments. From the derived Freundlich isotherm (FI) equation their binding capacity and binding strength were determined. Structurally similar compound resveratrol and a reference compound kirenol were used for investing the selective recognition capability of MMIPs. The MMIPs were used as sorbents for selective pre-concentration of rhaponticin from CPM samples. The contents of rhaponticin for the four CPM samples were found to be 11.84, 3.35, 4.47, and 7.57 μg g−1, respectively, and the recoveries of spiked samples ranged from 77.82% to 91.00%. The prepared MMIPs could be applied to selectively pre-concentrate and determine rhaponticin in CPM samples. |
| Keyword | Magnetic Molecularly Imprinted Polymers Rhaponticin Chinese Patent Medicines |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1016/j.chroma.2012.06.071 |
| Funding Organization | National Natural Science Foundation of China (no. 21075127;20875095) |
| Indexed By | SCI |
| If | 4.612 |
| Language | 英语 |
| Funding Project | 药物化学成分研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/19568 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Shi YP(师彦平) |
| Affiliation | 1.Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China 2.Graduate University of Chinese Academy of Sciences, Beijing 100039, China |
| Recommended Citation GB/T 7714 | Chen FF,Jie XY,Shi YP,et al. Magnetic molecularly imprinted polymer for the detection of rhaponticin in Chinese patent medicines[J]. Journal of Chromatography A,2012,1252:8-14. |
| APA | Chen FF,Jie XY,Shi YP,&师彦平.(2012).Magnetic molecularly imprinted polymer for the detection of rhaponticin in Chinese patent medicines.Journal of Chromatography A,1252,8-14. |
| MLA | Chen FF,et al."Magnetic molecularly imprinted polymer for the detection of rhaponticin in Chinese patent medicines".Journal of Chromatography A 1252(2012):8-14. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 20128-14.pdf（987KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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