| Highly efficient Suzuki cross-coupling reaction within an open channel plastic microreactor immobilized with palladium complexes | |
| Department | ERC国家工程研究中心 |
Li HL(李红玲)1; Gao, Xiaotong1; Ding, Hui1; Yang M(杨敏)2 ; Pu, Qiaosheng1; Yang M(杨敏)
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| 2012 | |
| Source Publication | Microfluidics and Nanofluidics
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| ISSN | 1613-4982 |
| Volume | 12Issue:6Pages:981-989 |
| Abstract | A practical open channel microfluidic reactor with immobilized palladium complex was built on a cyclic olefin copolymer (COC) chip that was fabricated with a very simple hot-embossing technique. Palladium complex was immobilized on a photochemically grafted layer of polymerized N-[3-(dimethylamino)propyl]methacrylamide. Surface modification and catalyst immobilization onto COC were systematically characterized with streaming potential, surface contact angle, attenuated total reflection Fourier transform infrared spectrometry, scanning electron microscopy, atomic force microscopy and X-ray photoelectron spectroscopy. The reactor was comprised of a single 15 cm long serpentine channel of 120 μm (i.d.) and exhibited high efficiency for the Suzuki cross-coupling reaction of aryl iodides and bromides with arylboronic acids, affording good to excellent yields of the corresponding products. The reactions could be carried out smoothly with reduced reaction time and lower reactant consumption in the microreactor thermostated at 50°C. The proposed system may have great potential for high-throughput screening of catalysts and reaction conditions. |
| Keyword | Microfluidic Reactor Suzuki Reaction Immobilized Palladium Cyclic Olefin Copolymer |
| Subject Area | 物理化学与绿色催化 |
| DOI | 10.1007/s10404-011-0932-0 |
| Funding Organization | the Key Project of Chinese Ministry of Education (No. 108119);the Natural Science Foundation of China (No. 20875041);the Program for New Century Excellent Talents in University (NCET-08-0255);the Fundamental Research Funds for the Central Universities (lzujbky-2012-k11) |
| Indexed By | SCI |
| If | 3.218 |
| Language | 英语 |
| Funding Project | 羰基粉体材料及催化剂研究组 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/19538 |
| Collection | 精细石油化工中间体国家工程研究中心（ERC） |
| Corresponding Author | Pu, Qiaosheng; Yang M(杨敏) |
| Affiliation | 1.Lanzhou Univ, Dept Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Natl Engn Res Ctr Fine Petrochem Intermediates, Lanzhou 730000, Gansu, Peoples R China |
| Recommended Citation GB/T 7714 | Li HL,Gao, Xiaotong,Ding, Hui,et al. Highly efficient Suzuki cross-coupling reaction within an open channel plastic microreactor immobilized with palladium complexes[J]. Microfluidics and Nanofluidics,2012,12(6):981-989. |
| APA | Li HL,Gao, Xiaotong,Ding, Hui,Yang M,Pu, Qiaosheng,&杨敏.(2012).Highly efficient Suzuki cross-coupling reaction within an open channel plastic microreactor immobilized with palladium complexes.Microfluidics and Nanofluidics,12(6),981-989. |
| MLA | Li HL,et al."Highly efficient Suzuki cross-coupling reaction within an open channel plastic microreactor immobilized with palladium complexes".Microfluidics and Nanofluidics 12.6(2012):981-989. |
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| art%3A10.1007%2Fs104（472KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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