| Preparative separation of Rebaudiana A from commercialized steviol glycosides by macroporous adsorption resins mixed bed | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Chen ZB(陈振斌)1,2,3; Wei, Xiaolan1,2; Li, Jie1,2; Di DL(邸多隆)3 ; Chen ZB(陈振斌)
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| 2012 | |
| Source Publication | Separation and Purification Technology
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| ISSN | 1383-5866 |
| Volume | 89Pages:22-30 |
| Abstract | This work focused on the separation and purification of commercialized steviol glycosides (SGs) by macroporous adsorption resins (MARs) mixed bed through the adsorption and desorption experiments. Firstly, the influence of functional groups on the separation degree of Rebaudiana A (RA) were investigated based on gel type ion exchange resins (GIRs), and the result showed the group of –N(CH3)2 was the best. Then, 21 sorts of MARs were screened one by one with adopting the separation degree of RA as the prior index, then the mixed bed of MARs that contained two, three, … till six were investigated in turn to find the most effective separation MARs mixed bed, and the results showed that MARs mixed bed LZ-1+LZ-20+LZ-30+LZ-37+LZ-36 had the higher separation efficiency than the others. Besides, the experimental data of MARs mixed bed LZ-1+LZ-20+LZ-30+LZ-37+LZ-36 well fitted the pseudo-second-order kinetics model and Brunauer’s IV adsorption isotherm model. And it was found that the intra-particle diffusion process was rate-limiting step. After that, the separation parameters of RA from commercialized SGs were optimized through adsorption and desorption experiments. And under the obtained optimum separation conditions, the separation degree increased from 0.838 to 0.9196 with a recovery yield of 91.67% through only one cycle adsorption and desorption. |
| Keyword | Separation Rebaudiana a Mars Mixed Bed |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1016/j.seppur.2012.01.001 |
| Funding Organization | the Graduate Tutor Program Funds of Gansu Provincial Department of Education (Grant No. 1001ZSB002) |
| Indexed By | SCI |
| If | 2.894 |
| Language | 英语 |
| Funding Project | 药物工艺标准研究组 |
| compositor | 第三作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/19415 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Chen ZB(陈振斌) |
| Affiliation | 1.Lanzhou Univ Technol, Sch Mat Sci & Engn, Lanzhou 730050, Gansu, Peoples R China 2.Lanzhou Univ Technol, State Key Lab Gansu Adv Nonferrous Met Mat, Lanzhou 730050, Gansu, Peoples R China 3.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730050, Gansu, Peoples R China |
| Recommended Citation GB/T 7714 | Chen ZB,Wei, Xiaolan,Li, Jie,et al. Preparative separation of Rebaudiana A from commercialized steviol glycosides by macroporous adsorption resins mixed bed[J]. Separation and Purification Technology,2012,89:22-30. |
| APA | Chen ZB,Wei, Xiaolan,Li, Jie,Di DL,&陈振斌.(2012).Preparative separation of Rebaudiana A from commercialized steviol glycosides by macroporous adsorption resins mixed bed.Separation and Purification Technology,89,22-30. |
| MLA | Chen ZB,et al."Preparative separation of Rebaudiana A from commercialized steviol glycosides by macroporous adsorption resins mixed bed".Separation and Purification Technology 89(2012):22-30. |
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| File Name/Size | DocType | Version | Access | License | ||
| 1-s2.0-S138358661200（403KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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