| Synthesis of Functional Adsorption Resin and Its Adsorption Properties in Purification of Flavonoids from Hippophae rhamnoides L. Leaves | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Lou S(娄嵩)1,2,3; Chen ZB(陈振斌)1,2,4; Liu YF(刘永峰)1,2,3 ; Ye HL(叶鹤林)1,2,3; Di DL(邸多隆)1,2; Di DL(邸多隆)
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| 2012 | |
| Source Publication | Industrial and Engineering Chemistry Research
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| ISSN | 0888-5885 |
| Volume | 51Issue:6Pages:2682-2696 |
| Abstract | The efficient purification method of high purity flavonoids from Hippophae rhamnoides L. (sea buckthorn) was reported. A series of adsorption resins with novel structure were synthesized on the basis of the Friedel-Crafts catalyzed and amination reaction. Functional groups, such as the chloromethyl or the amino group, were introduced into the resin matrix, respectively, to raise the specific surface area, produce the hydrogen-bonding interaction, and enhance the adsorption selectivity toward flavone compounds. The results showed that the adsorbent DDM-1 with 0.44 mmol/g chloromethyl groups and the adsorbent DDM-2 with 0.68 mmol/g amino groups performed high purity and adsorption to flavone compounds in Hippophae rhamnoides L. leaves, respectively, obviously higher than that from commercial adsorbents due to their more pores, higher surface area and pore size, and stronger hydrogen-bonding interaction between flavonoids and surface functional groups of the adsorbents, which maintained the adsorption driving force. The isotherms and kinetics of synthetic resins were also studied systematically. In order to get the optimal sample, the No. 3 and No. H were selected and used in the developed two-separation-step protocol due to their high adsorption and purity capacities, respectively. The purity of flavonoids after the two steps was increased 6.62-fold from 5.55% to 36.75%. The method showed its universality via good effects on the purification of flavonoids from Hippophae rhamnoides L. leaves. |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1021/ie201494k |
| Funding Organization | the Hundred Talents Program of the Chinese Academy of science (CAS);the National Natural Science Foundation of China (NSFC, no. 20974116) |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 药物工艺标准研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/19343 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Di DL(邸多隆) |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem NW Plant Resources, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 4.Lanzhou Univ Technol, State Key Lab Gansu Adv Nonferrous Met Mat, Lanzhou 730050, Peoples R China |
| Recommended Citation GB/T 7714 | Lou S,Chen ZB,Liu YF,et al. Synthesis of Functional Adsorption Resin and Its Adsorption Properties in Purification of Flavonoids from Hippophae rhamnoides L. Leaves[J]. Industrial and Engineering Chemistry Research,2012,51(6):2682-2696. |
| APA | Lou S,Chen ZB,Liu YF,Ye HL,Di DL,&邸多隆.(2012).Synthesis of Functional Adsorption Resin and Its Adsorption Properties in Purification of Flavonoids from Hippophae rhamnoides L. Leaves.Industrial and Engineering Chemistry Research,51(6),2682-2696. |
| MLA | Lou S,et al."Synthesis of Functional Adsorption Resin and Its Adsorption Properties in Purification of Flavonoids from Hippophae rhamnoides L. Leaves".Industrial and Engineering Chemistry Research 51.6(2012):2682-2696. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| ie201494k.pdf（2850KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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