| A novel fullerene oxide functionalized silica composite as stationary phase for high performance liquid chromatography | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Liu HM(刘后梅)1,2; Guo Y(郭勇)1 ; Wang XS(王旭生)1; Liang XJ(梁晓静)1; Liu X(刘霞)1; Jiang SX(蒋生祥)1; Liang XJ(梁晓静); Liu X(刘霞)
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| 2014 | |
| Source Publication | RSC Advances
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| ISSN | 2046-2069 |
| Volume | 4Issue:34Pages:17541-17548 |
| Abstract | Hydrophilic interaction liquid chromatography has been widely used for separating hydrophilic compounds and the development of new stationary phases for HILIC is significant. In this study, fullerene oxide was successfully assembled onto silica microspheres to form a FO-modified silica stationary phase. The synthesized material was characterized by elemental analysis, transmission electron microscopy, Raman spectroscopy and contact angle analysis. The chromatographic properties of the stationary phase were investigated in HILIC mode for analysis of nucleosides, nucleobases, water soluble vitamins, amino acids and saccharides. Good separations of these compounds were achieved on the resulting column. Compared with the aminopropylated silica column, FO/SiO2 column exhibited better separation efficiency. This study also investigated the effect of various experimental factors on the retention of the polar stationary phases, such as acetonitrile content and salt concentration in the mobile phase. |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1039/c4ra01408a |
| Funding Organization | the National Natural Science Foundation of China (21105107;21175143;20905072) |
| Indexed By | SCI |
| If | 3.840 |
| Language | 英语 |
| Funding Project | 药物分离材料研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/19277 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Liang XJ(梁晓静); Liu X(刘霞) |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Liu HM,Guo Y,Wang XS,et al. A novel fullerene oxide functionalized silica composite as stationary phase for high performance liquid chromatography[J]. RSC Advances,2014,4(34):17541-17548. |
| APA | Liu HM.,Guo Y.,Wang XS.,Liang XJ.,Liu X.,...&刘霞.(2014).A novel fullerene oxide functionalized silica composite as stationary phase for high performance liquid chromatography.RSC Advances,4(34),17541-17548. |
| MLA | Liu HM,et al."A novel fullerene oxide functionalized silica composite as stationary phase for high performance liquid chromatography".RSC Advances 4.34(2014):17541-17548. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| c4ra01408a.pdf（466KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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