| Liquid-liquid/solid three-phase high-speed counter-current chromatography based on O-carboxymethyl chitosan-functionalized multi-walled carbon nanotubes as solvent additive | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Liu YJ(刘言娟)1,2,3 ; Liu YF(刘永峰)1,2; Wang GH(王高红)1,2,3; Di DL(邸多隆)1,2; Di DL(邸多隆)
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| 2014 | |
| Source Publication | RSC Advances
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| ISSN | 2046-2069 |
| Volume | 4Issue:50Pages:26231-26239 |
| Abstract | O-Carboxymethyl chitosan-functionalized multi-walled carbon nanotubes (MWCNTs/OMCS) were found to be a novel additive for high-speed counter-current chromatography (HSCCC). It was shown that a kind of liquid–liquid/solid (LLS) three-phase HSCCC system can be established with MWCNTs/OMCS as additive, and in this HSCCC system liquid–liquid partition chromatography and liquid–solid adsorption chromatography were combined. This study revealed that MWCNTs/OMCS can obviously improve peak resolution (Rs). Three flavonol aglycons (quercetin, luteolin and kaempferol) were used as model analytes to study the mechanisms of MWCNTs/OMCS as HSCCC solvent additive to improve Rs. It was indicated that MWCNTs/OMCS improved Rs not by increasing the stationary phase retention but by introducing intermolecular forces: electrostatic interaction, hydrogen bonding interaction and π–π conjugation. |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1039/c4ra03222e |
| Funding Organization | the National Natural Science Foundation of China (NSFC no. 20775083;no. 21175142);Open Fund of Key Laboratory of Chemistry of Northwestern Plant Resources of the Chinese Academy of Sciences (no. CNPR-2011kfkt-02) |
| Indexed By | SCI |
| If | 3.840 |
| Language | 英语 |
| Funding Project | 药物工艺标准研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/19224 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Di DL(邸多隆) |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Liu YJ,Liu YF,Wang GH,et al. Liquid-liquid/solid three-phase high-speed counter-current chromatography based on O-carboxymethyl chitosan-functionalized multi-walled carbon nanotubes as solvent additive[J]. RSC Advances,2014,4(50):26231-26239. |
| APA | Liu YJ,Liu YF,Wang GH,Di DL,&邸多隆.(2014).Liquid-liquid/solid three-phase high-speed counter-current chromatography based on O-carboxymethyl chitosan-functionalized multi-walled carbon nanotubes as solvent additive.RSC Advances,4(50),26231-26239. |
| MLA | Liu YJ,et al."Liquid-liquid/solid three-phase high-speed counter-current chromatography based on O-carboxymethyl chitosan-functionalized multi-walled carbon nanotubes as solvent additive".RSC Advances 4.50(2014):26231-26239. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| c4ra03222e.pdf（855KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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