| In Vivo Biodistribution and Toxicity of Highly Soluble PEG-Coated Boron Nitride in Mice | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Liu, Bo1; Qi, Wei2; Tian, Longlong1; Li Z(李湛)3; Miao, Guoying4; An, Wenzhen5; Liu, Dan1; Lin, Jing1; Zhang, Xiaoyong6; Wu WS(吴王锁)1; Li Z(李湛); Wu WS(吴王锁) | |
| 2015 | |
| Source Publication | Nanoscale Research Letters
 |
| ISSN | 1556-276X |
| Volume | 10Pages:478(1-7) |
| Abstract | The boron nitride (BN) nanoparticles, as the structural analogues of graphene, are the potential biomedicine materials because of the excellent biocompatibility, but their solubility and biosafety are the biggest obstacle for the clinic application. Here, we first synthesized the highly soluble BN nanoparticles coated by PEG (BN-PEG) with smaller size (similar to 10 nm), then studied their biodistribution in vivo through radioisotope ((Tc99mO-4) labeling, and the results showed that BN-PEG nanoparticles mainly accumulated in the liver, lung, and spleen with the less uptake by the brain. Moreover, the pathological changes induced by BN-PEG could be significantly observed in the sections of the liver, lung, spleen, and heart, which can be also supported by the test of biochemical indexes in serum. More importantly, we first observed the biodistribution of BN-PEG in the heart tissues with high toxicity, which would give a warning about the cardiovascular disease, and provide some opportunities for the drug delivery and treatment. |
| Keyword | Biodistribution Toxicity Soluble Boron Nitride (Bn) |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1186/s11671-015-1172-0 |
| Funding Organization | the National Science Foundation of China NO. J1210001;21327801 |
| Indexed By | SCI |
| If | 2.584 |
| Language | 英语 |
| Funding Project | 药物分离材料研究组 |
| compositor | 第三作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/19192 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Qi, Wei; Li Z(李湛); Wu WS(吴王锁) |
| Affiliation | 1.Lanzhou Univ, Radiochem Lab, Lanzhou 730000, Gansu, Peoples R China 2.Huazhong Univ Sci & Technol, Wuhan 430074, Peoples R China 3.Chinese Acad Sci, Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Gansu, Peoples R China 4.Gansu Prov Hosp, Dept Radiotherapy, Lanzhou 730000, Gansu, Peoples R China 5.Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Gansu, Peoples R China 6.Nanchang Univ, Dept Chem, Nanchang 330031, Peoples R China |
| Recommended Citation GB/T 7714 | Liu, Bo,Qi, Wei,Tian, Longlong,et al. In Vivo Biodistribution and Toxicity of Highly Soluble PEG-Coated Boron Nitride in Mice[J]. Nanoscale Research Letters,2015,10:478(1-7). |
| APA | Liu, Bo.,Qi, Wei.,Tian, Longlong.,Li Z.,Miao, Guoying.,...&吴王锁.(2015).In Vivo Biodistribution and Toxicity of Highly Soluble PEG-Coated Boron Nitride in Mice.Nanoscale Research Letters,10,478(1-7). |
| MLA | Liu, Bo,et al."In Vivo Biodistribution and Toxicity of Highly Soluble PEG-Coated Boron Nitride in Mice".Nanoscale Research Letters 10(2015):478(1-7). |
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| File Name/Size | DocType | Version | Access | License | ||
| art%3A10.1186%2Fs116（1767KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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