Development of Ar-BINMOL-Derived Atropisomeric Ligands with Matched Axial and sp(3) Central Chirality for Catalytic Asymmetric Transformations | |
Department | OSSO国家重点实验室 |
Xu, Zheng1; Xu LW(徐利文)1,2; Xu LW(徐利文) | |
2015 | |
Source Publication | Chemical Record |
ISSN | 1527-8999 |
Volume | 15Issue:5Pages:925-948 |
Abstract | Recently, academic chemists have renewed their interest in the development of 1,1′-binaphthalene-2,2′-diol (BINOL)-derived chiral ligands. Six years ago, a working hypothesis, that the chirality matching of hybrid chirality on a ligand could probably lead to high levels of stereoselective induction, prompted us to use the axial chirality of BINOL derivatives to generate new stereogenic centers within the same molecule with high stereoselectivity, obtaining as a result sterically favorable ligands for applications in asymmetric catalysis. This Personal Account describes our laboratory's efforts toward the development of a novel class of BINOL-derived atropisomers bearing both axial and sp3 central chirality, the so-called Ar-BINMOLs, for asymmetric synthesis. Furthermore, on the basis of the successful application of Ar-BINMOLs and their derivatives in asymmetric catalysis, the search for highly efficient and enantioselective processes also compelled us to give special attention to the BINOL-derived multifunctional ligands with multiple stereogenic centers for use in catalytic asymmetric reactions. |
Keyword | Asymmetric Catalysis Atropisomerism Binols Chirality Wittig Rearrangements |
Subject Area | 物理化学与绿色催化 |
DOI | 10.1002/tcr.201500208 |
Funding Organization | the National Natural Science Foundation of China (No. 21173064;21472031);the Zhejiang Provincial Natural Science Foundation of China (LR14B030001) |
Indexed By | SCI |
If | 3.459 |
Language | 英语 |
compositor | 第二作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/19078 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) |
Corresponding Author | Xu LW(徐利文) |
Affiliation | 1.Hangzhou Normal Univ, Key Lab Organosilicon Chem & Mat Technol, Minist Educ, Hangzhou, Zhejiang, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
Recommended Citation GB/T 7714 | Xu, Zheng,Xu LW,Xu LW. Development of Ar-BINMOL-Derived Atropisomeric Ligands with Matched Axial and sp(3) Central Chirality for Catalytic Asymmetric Transformations[J]. Chemical Record,2015,15(5):925-948. |
APA | Xu, Zheng,Xu LW,&徐利文.(2015).Development of Ar-BINMOL-Derived Atropisomeric Ligands with Matched Axial and sp(3) Central Chirality for Catalytic Asymmetric Transformations.Chemical Record,15(5),925-948. |
MLA | Xu, Zheng,et al."Development of Ar-BINMOL-Derived Atropisomeric Ligands with Matched Axial and sp(3) Central Chirality for Catalytic Asymmetric Transformations".Chemical Record 15.5(2015):925-948. |
Files in This Item: | ||||||
File Name/Size | DocType | Version | Access | License | ||
LZ01028471.pdf(1664KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment