| Effect of Ionic Liquids as Additive on the Separation of Bases and Amino acids in HPLC | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Qiong Jiang1 ; Qiu HD(邱洪灯)2,3; Wang XS(王旭生)2; Liu X(刘霞)2; Shusheng Zhang1
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| 2008 | |
| Source Publication | Journal of Liquid Chromatography & Related Technologies
 |
| ISSN | 1082-6076 |
| Volume | 31Pages:1448-1457 |
| Abstract | In this paper, four bases, including cytosine, thymine, adenine, 6-chlorouracil and four amino acids, including L-histidine, L-tyrosine, L-phenylalanine, and DLtryptophane, were separated with different types of ionic liquids as additives for the mobile phase in high-performance liquid chromatography. Four different ILs, including 1-ethyl-3-methylimidazolium tetrafluoroborate, 1-butyl-3-methylimidazolium tetrafluoroborate, 1-hexyl-3-methylimidazolium tetrafluoroborate, and 1-butyl-3-methylimidazolium chloride were used. The effects of the length of the alkyl group on the imidazolium ring and its counterion, the concentrations of the ionic liquids on the retention factor of the bases and amino acids are investigated. The results showed that the retention and resolution of the bases and amino acids were improved when ionic liquids were used as additives. The mechanism at the separation with ionic liquids as additive to mobile phase is discussed. |
| Keyword | Ionic Liquid Additive Base Amino Acid High-performance Liquid Chromatography |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1080/10826070802039424 |
| Funding Organization | the National Natural Science Foundation of China (NSFC, NO.20475058;NO. 20527005) |
| Language | 英语 |
| Funding Project | 药物分离材料研究组 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/18892 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Shusheng Zhang |
| Affiliation | 1.Key Laboratory of Chemical Biology and Organic Chemistry of Henan, Chemistry Department, Zhengzhou University, Zhengzhou, P. R. China 2.Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, P. R. China 3.Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, P. R. China |
| Recommended Citation GB/T 7714 | Qiong Jiang,Qiu HD,Wang XS,et al. Effect of Ionic Liquids as Additive on the Separation of Bases and Amino acids in HPLC[J]. Journal of Liquid Chromatography & Related Technologies,2008,31:1448-1457. |
| APA | Qiong Jiang,Qiu HD,Wang XS,Liu X,&Shusheng Zhang.(2008).Effect of Ionic Liquids as Additive on the Separation of Bases and Amino acids in HPLC.Journal of Liquid Chromatography & Related Technologies,31,1448-1457. |
| MLA | Qiong Jiang,et al."Effect of Ionic Liquids as Additive on the Separation of Bases and Amino acids in HPLC".Journal of Liquid Chromatography & Related Technologies 31(2008):1448-1457. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 2008-JLCRT-jiang.pdf（248KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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