| A new imidazolium-embedded C-18 stationary phase with enhanced performance in reversed-phase liquid chromatography | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Qiu HD(邱洪灯)1,2 ; Mallik, Abul K.1; Takafuji, Makoto1,3; Liu X(刘霞)2; Jiang SX(蒋生祥)2; Ihara, Hirotaka1,3; Hirotaka Ihara
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| 2012 | |
| Source Publication | Analytica Chimica Acta
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| ISSN | 0003-2670 |
| Volume | 738Pages:95-101 |
| Abstract | In this paper, a new imidazolium-embedded C18 stationary phase (SiImC18) for reversed-phase high-performance liquid chromatography is described. 1-Allyl-3-octadecylimidazolium bromide ionic liquid compound having a long alkyl chain and reactive groups was newly prepared and grafted onto 3-mercaptopropyltrimethoxysilane-modified silica via a surface-initiated radical-chain transfer addition reaction. The SiImC18 obtained was characterized by elemental analysis, infrared spectroscopy, thermogravimetric analysis, diffuse reflectance infrared Fourier transform, and solid-state 13C and 29Si cross-polarization/magic angle spinning nuclear magnetic resonance spectroscopy. The selectivity toward polycyclic aromatic hydrocarbons relative to that toward alkylbenzenes exhibited by SiImC18 was higher than the corresponding selectivity exhibited by a conventional octadecyl silica (ODS) column, which could be explained by electrostatic π–π interaction cationic imidazolium and electron-rich aromatic rings. On the other hand, SiImC18 also showed high selectivity for polar compounds, which was based on the multiple interaction and retention mechanisms of this phase with different analytes. 1,6-Dinitropyrene and 1,8-dinitropyrene, which form a positional isomer pair of dipolar compounds, were separated successfully with the SiImC18 phase. Seven nucleosides and bases (i.e. cytidine, uracil, uridine, thymine, guanosine, xanthosine, and adenosine) were separated using only water as the mobile phase within 8 min, which is difficult to achieve when using conventional hydrophobic columns such as ODS. The combination of electrostatic and hydrophobic interactions is important for the effective separation of such basic compounds without the use of any organic additive as the eluent in the octadecylimidazolium column. |
| Keyword | Ionic Liquids Imidazolium Ods Stationary Phase Embedded Polar Group |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1016/j.aca.2012.06.018 |
| Indexed By | SCI |
| If | 4.387 |
| Language | 英语 |
| Funding Project | 药物分离材料研究组 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/18882 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Hirotaka Ihara |
| Affiliation | 1.Kumamoto Univ, Dept Appl Chem & Biochem, Kumamoto 8608555, Japan 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China 3.Kumamoto Inst Photoelectro Organ Phoen, Kumamoto 8620901, Japan |
| Recommended Citation GB/T 7714 | Qiu HD,Mallik, Abul K.,Takafuji, Makoto,et al. A new imidazolium-embedded C-18 stationary phase with enhanced performance in reversed-phase liquid chromatography[J]. Analytica Chimica Acta,2012,738:95-101. |
| APA | Qiu HD.,Mallik, Abul K..,Takafuji, Makoto.,Liu X.,Jiang SX.,...&Hirotaka Ihara.(2012).A new imidazolium-embedded C-18 stationary phase with enhanced performance in reversed-phase liquid chromatography.Analytica Chimica Acta,738,95-101. |
| MLA | Qiu HD,et al."A new imidazolium-embedded C-18 stationary phase with enhanced performance in reversed-phase liquid chromatography".Analytica Chimica Acta 738(2012):95-101. |
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| File Name/Size | DocType | Version | Access | License | ||
| 2012-ACA-Qiu.PDF（1378KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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