| Double carboxyl silicane modified graphene oxide coated silica composite as sorbent for solid-phase extraction of quarternary alkaloids | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Liu HM(刘后梅)1,2 ; Guo Y(郭勇)1; Wang XS(王旭生)1; Li YK(李易坤)3; Liang XJ(梁晓静)1; Liu X(刘霞)1; Liu X(刘霞); Liang XJ(梁晓静)
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| 2015 | |
| Source Publication | Analytical Methods
 |
| ISSN | 1759-9660 |
| Volume | 7Pages:135-142 |
| Abstract | In this paper, a novel sorbent, double carboxyl silicane modified graphene oxide coated silica has been prepared and used as sorbent for solid-phase extraction of quarternary alkaloids. The synthesized sorbent material was characterized by elemental analysis and field emission scanning electron microscopy. The extraction properties of the developed sorbent were evaluated by four quarternary alkaloids: coptisine chloride, sanguinarine, berberine chloride and chelerythrine. Multiple interactions, i.e., electrostatic, hydrogen bonding and dipole–dipole interactions, take place during the extraction. After the optimization of conditions, several parameters, such as volume of sample loading, pH of sample, pH of eluent and sample loading velocity, were set up. Under the optimal conditions, good linearities with R2 ranging from 0.9990 to 0.9995 were obtained for the four compounds. The LODs were found to be in the range of 1–2 μg L_1, and the LOQs were found to be in the range of 2–5 μg L_1. The recoveries of the four quarternary alkaloids spiked with 5 μg L_1 in human urine samples ranged from 89.1% to 110.6% with RSDs in the range of 2.6–10.4%. The results showed that the new sorbent has excellent extraction capacity for the tested quarternary alkaloids. |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1039/c4ay02172j |
| Funding Organization | the National Natural Science Foundation of China (21105107;21175143;21475143);the National Science & Technology Major Project of China (nos 2011ZX05010003;2011ZX05011) |
| Indexed By | SCI |
| If | 1.915 |
| Language | 英语 |
| Funding Project | 药物分离材料研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/18844 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Liu X(刘霞); Liang XJ(梁晓静) |
| Affiliation | 1.Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China 2.University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100049, China 3.Key Laboratory of Oil & Gas Production, China National Petroleum Corporation (CNPC), Research Institute of Petroleum Exploration and Development (RIPED), Beijing, 100083, China |
| Recommended Citation GB/T 7714 | Liu HM,Guo Y,Wang XS,et al. Double carboxyl silicane modified graphene oxide coated silica composite as sorbent for solid-phase extraction of quarternary alkaloids[J]. Analytical Methods,2015,7:135-142. |
| APA | Liu HM.,Guo Y.,Wang XS.,Li YK.,Liang XJ.,...&梁晓静.(2015).Double carboxyl silicane modified graphene oxide coated silica composite as sorbent for solid-phase extraction of quarternary alkaloids.Analytical Methods,7,135-142. |
| MLA | Liu HM,et al."Double carboxyl silicane modified graphene oxide coated silica composite as sorbent for solid-phase extraction of quarternary alkaloids".Analytical Methods 7(2015):135-142. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 刘后梅-05010-11.pdf（958KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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