| Low-Temperature Hydrothermal Synthesis of Hierarchical Porous Hydroxyapatite Microsphere with Co-substituted Essential Trace Elements for pH-responsive Drug Delivery | |
| Department | 固体润滑国家重点实验室 |
Wang S(王莎)1,2; Guo ZG(郭志光)1,2 ; Guo ZG(郭志光)
| |
| 2015 | |
| Source Publication | Nano Life
 |
| ISSN | 1793-9844 |
| Volume | 5Issue:1Pages:154001(1-12) |
| Abstract | Hierarchical hydroxyapatite microspheres composed of two porous hemispherulites have been synthesized hydrothermally at 80_C. A possible formation mechanism was proposed. The drug loading and release properties were further investigated. 3D hierarchical microspheric hydroxyapatite (HAp) composed of two porous hemispherulites was hydrothermally fabricated at low temperature with the aid of urea and NaNO3, Mg(NO3)2, KNO3, NH4Cl and NH4F as the homogeneous precipitation reagent and substituted ion sources. In this novel strategy, the element-substitutions serve as regulating agents for the self-assembly of porous HAp microspheres from the dumbbell-like particles to two hemispheres with radius of about 10 μm. Furthermore, the as-prepared hierarchical HAp microspheres exhibit high drug-loading capability and superior sustained release properties, which make it a promising carrier for pH responsive drug delivery system. |
| Keyword | Porous Hydroxyapatite Microsphere Drug Delivery Hydrothermal Method Degradation |
| Subject Area | 材料科学与物理化学 |
| DOI | 10.1142/S1793984415400012 |
| Funding Organization | the National Nature Science Foundation of China (No. 31070155;11172301;21203217);the “Funds for Distinguished Young Scientists” of Hubei Province (2012FFA002);the “Western Light Talent Culture" Project;the Co-joint Project of Chinese Academy of Sciences;the “Top Hundred Talents" Program of Chinese Academy of Sciences;the National 973 Project (2013CB632300) |
| Language | 英语 |
| Funding Project | 空间润滑材料组 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/18824 |
| Collection | 固体润滑国家重点实验室（LSL） |
| Corresponding Author | Guo ZG(郭志光) |
| Affiliation | 1.Hubei Collaborative Innovation Centre for Advanced Organic Chemical Materials and Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei University Wuhan 430062, P. R. China 2.State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences Lanzhou 730000, P. R. China |
| Recommended Citation GB/T 7714 | Wang S,Guo ZG,Guo ZG. Low-Temperature Hydrothermal Synthesis of Hierarchical Porous Hydroxyapatite Microsphere with Co-substituted Essential Trace Elements for pH-responsive Drug Delivery[J]. Nano Life,2015,5(1):154001(1-12). |
| APA | Wang S,Guo ZG,&郭志光.(2015).Low-Temperature Hydrothermal Synthesis of Hierarchical Porous Hydroxyapatite Microsphere with Co-substituted Essential Trace Elements for pH-responsive Drug Delivery.Nano Life,5(1),154001(1-12). |
| MLA | Wang S,et al."Low-Temperature Hydrothermal Synthesis of Hierarchical Porous Hydroxyapatite Microsphere with Co-substituted Essential Trace Elements for pH-responsive Drug Delivery".Nano Life 5.1(2015):154001(1-12). |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 王莎 Nanolife.pdf（1285KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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