| One-pot three-component reactions of methyl ketones, phenols and a nucleophile: an expedient way to synthesize densely substituted benzofurans | |
| Department | OSSO国家重点实验室 |
| Cheng, Cheng1; Liu, Changhui1; Gu YL(顾彦龙)1,2; Gu YL(顾彦龙) | |
| 2015 | |
| Source Publication | Tetrahedron
 |
| ISSN | 0040-4020 |
| Volume | 71Issue:42Pages:8009-8017 |
| Abstract | Three-component reactions of phenylglyoxal monohydrate, phenols, and indoles were developed with the aid of acid-catalyst, which produced various densely substituted benzofurans with good to excellent yields. On the basis of this observation, a one-pot, step-wise reaction was developed by using methyl ketones instead of using phenylglyoxal component in I2/DMSO system. At last, three-component reaction offered a useful way to synthesize densely substituted benzofurans starting from simple and easily available substrates. The indole component can be replaced by some other nucleophiles, such as 1,2,4-trimethoxybenzene and thiophenol. |
| Keyword | Multi-component Reactions Benzofurans Methyl Ketone Phenylglyoxal |
| Subject Area | 物理化学与绿色催化 |
| DOI | 10.1016/j.tet.2015.08.058 |
| Funding Organization | National Natural Science Foundation of China (21173089;21373093);Chutian Scholar Program of the Hubei Provincial Government and the Cooperative Innovation Center of Hubei Province; the Fundamental Research Funds for the Central Universities of China (2014ZZGH019) |
| Indexed By | SCI |
| If | 2.645 |
| Language | 英语 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/18677 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Gu YL(顾彦龙) |
| Affiliation | 1.Huazhong Univ Sci & Technol, Key Lab Large Format Battery Mat & Syst, Minist Educ, Sch Chem & Chem Engn, Wuhan 430074, Peoples R China 2.Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Cheng, Cheng,Liu, Changhui,Gu YL,et al. One-pot three-component reactions of methyl ketones, phenols and a nucleophile: an expedient way to synthesize densely substituted benzofurans[J]. Tetrahedron,2015,71(42):8009-8017. |
| APA | Cheng, Cheng,Liu, Changhui,Gu YL,&顾彦龙.(2015).One-pot three-component reactions of methyl ketones, phenols and a nucleophile: an expedient way to synthesize densely substituted benzofurans.Tetrahedron,71(42),8009-8017. |
| MLA | Cheng, Cheng,et al."One-pot three-component reactions of methyl ketones, phenols and a nucleophile: an expedient way to synthesize densely substituted benzofurans".Tetrahedron 71.42(2015):8009-8017. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 1-s2.0-S004040201530（716KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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