Application of a C-C Bond-Forming Conjugate Addition Reaction in Asymmetric Dearomatization of beta-Naphthols

doi:10.1002/anie.201503056

	Application of a C-C Bond-Forming Conjugate Addition Reaction in Asymmetric Dearomatization of beta-Naphthols
Department	OSSO国家重点实验室
	Yang, Dongxu 1; Wang, Linqing 1; Kai, Ming 1; Li, Dan 1; Yao, Xiaojun 1; Wang R(王锐)1,2; Wang R(王锐)
	2015
Source Publication	Angewandte Chemie International Edition
ISSN	1433-7851
Volume	54 Issue:33 Pages:9523-9527
Abstract	A CC bond-forming conjugate reaction was successfully applied to the enantioselective dearomatization of β-naphthols. A C(sp2)C(sp3) bond is formed by using propargylic ketones as reactive partners. Good to excellent Z/E ratios and ee values were obtained by employing an in situ generated magnesium catalyst. Further transformations of the Z-configured CC double bond in the products were achieved under mild reaction conditions. Moreover, the stereocontrolling element of this magnesium-catalyzed dearomatization reaction was explored by computational chemistry.
Keyword	Arenes Aromaticity Dft Calculations Magnesium Naphthols
Subject Area	物理化学与绿色催化
DOI	10.1002/anie.201503056
Funding Organization	the NSFC (21432003;81473095;91213302;91413107);the National S&T Major Project of China (2012ZX09504001-003);the Program for Changjiang Scholars and Innovative Research Team in University (IRT1137)
Indexed By	SCI
If	11.261
Language	英语
compositor	第二作者单位
Citation statistics	Cited Times:93[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.licp.cn/handle/362003/18550
Collection	羰基合成与选择氧化国家重点实验室（OSSO）
Corresponding Author	Wang R(王锐)
Affiliation	1.Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China
Recommended Citation GB/T 7714	Yang, Dongxu,Wang, Linqing,Kai, Ming,et al. Application of a C-C Bond-Forming Conjugate Addition Reaction in Asymmetric Dearomatization of beta-Naphthols[J]. Angewandte Chemie International Edition,2015,54(33):9523-9527.
APA	Yang, Dongxu.,Wang, Linqing.,Kai, Ming.,Li, Dan.,Yao, Xiaojun.,...&王锐.(2015).Application of a C-C Bond-Forming Conjugate Addition Reaction in Asymmetric Dearomatization of beta-Naphthols.Angewandte Chemie International Edition,54(33),9523-9527.
MLA	Yang, Dongxu,et al."Application of a C-C Bond-Forming Conjugate Addition Reaction in Asymmetric Dearomatization of beta-Naphthols".Angewandte Chemie International Edition 54.33(2015):9523-9527.

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