| Preparation and application of a novel mixed-mode monolith for reversed-phase and per aqueous capillary electrochromatography | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Tang S(汤胜)1,2 ; Guo Y(郭勇)1; Liang XJ(梁晓静)1; Wei, Falin3; Yang, Limin3; Liu SJ(刘淑娟)1; Liu X(刘霞)1; Jiang SX(蒋生祥)1; Liu SJ(刘淑娟); Liu X(刘霞)
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| 2015 | |
| Source Publication | Analytical Methods
 |
| ISSN | 1759-9660 |
| Volume | 7Issue:11Pages:4750-4756 |
| Abstract | A novel mixed-mode monolithic stationary phase based on bonding of 4,5-imidazoledicarboxy acid to the surface of an organic-silica hybrid monolith was prepared and characterized. Satisfactory characteristics in terms of mechanical stability, permeability and reproducibility of the resultant monolithic column were achieved. A typical per aqueous chromatographic behavior was observed in water-rich mobile phases. The resultant monolithic column was applied for the efficient resolution of various polar and hydrophilic compounds under per aqueous or reversed-phase chromatographic conditions, which successfully demonstrated its suitability for the analysis of these polar compounds in highly aqueous mobile phases. The highest column efficiency obtained for the amines was 149 000 N m−1. The experimental results showed that the mixed-mode mechanism of hydrophobic and ion-exchange interactions was involved in the separation under the given conditions. The successful applications suggested that the mixed-mode organic-silica hybrid monolithic column could offer a wide range of retention behaviors and flexible selectivities toward polar compounds, achieving various target separations. |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1039/c5ay00611b |
| Funding Organization | the National Natural Science Foundation of China (nos. 21475143;21175143;20905072);the National Science & Technology Major Project of China (nos. 2011ZX05010-003;2011ZX05011) |
| Indexed By | SCI |
| If | 1.821 |
| Language | 英语 |
| Funding Project | 药物分离材料研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/18468 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Liu SJ(刘淑娟); Liu X(刘霞) |
| Affiliation | 1.Key Laboratory of Chemistry of Northwestern Plant Resources, CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China 2.University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100049, China 3.Key Laboratory of Oil & Gas Production, China National Petroleum Corporation (CNPC) and Research Institute of Petroleum Exploration and Development (RIPED), Beijing 100083, China |
| Recommended Citation GB/T 7714 | Tang S,Guo Y,Liang XJ,et al. Preparation and application of a novel mixed-mode monolith for reversed-phase and per aqueous capillary electrochromatography[J]. Analytical Methods,2015,7(11):4750-4756. |
| APA | Tang S.,Guo Y.,Liang XJ.,Wei, Falin.,Yang, Limin.,...&刘霞.(2015).Preparation and application of a novel mixed-mode monolith for reversed-phase and per aqueous capillary electrochromatography.Analytical Methods,7(11),4750-4756. |
| MLA | Tang S,et al."Preparation and application of a novel mixed-mode monolith for reversed-phase and per aqueous capillary electrochromatography".Analytical Methods 7.11(2015):4750-4756. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| c5ay00611b.pdf（462KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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