| The asymmetric synthesis of CF3-containing spiro[pyrrolidin-3,2 '-oxindole] through the organocatalytic 1,3-dipolar cycloaddition reaction | |
| Department | OSSO国家重点实验室 |
| Ma, Mingxia1; Zhu, Yuanyuan1; Sun, Quantao1; Li, Xiaoyuan1; Su, Jinhuan1; Zhao, Long1; Zhao, Yanyan1; Qiu, Shuai1; Yan, Wenjin1; Wang, Kairong1; Wang R(王锐)1,2; Wang R(王锐) | |
| 2015 | |
| Source Publication | Chemical Communications
 |
| ISSN | 1359-7345 |
| Volume | 51Issue:42Pages:8789-8792 |
| Abstract | A new strategy for the construction of optically active 5′-CF3 spiro[pyrrolidin-3,2′-oxindole] was described. A series of unprecedented 1,3-dipoles were obtained by condensation of CF3CH2NH2 with isatins. The 1,3-dipolar cycloaddition reactions of these ketimines with enals gave the products bearing four contiguous stereogenic centers in excellent yields, diastereoselectivities and enantioselectivities. |
| Subject Area | 物理化学与绿色催化 |
| DOI | 10.1039/c4cc10216a |
| Funding Organization | the National Natural Science Foundation of China (No. 21432003;21272108;31200584);the Key National S&T Program ‘‘Major New Drug Development’’ of the Ministry of Science and Technology of China (2012ZX09504001-003);the Innovation Group of Gansu Province (1210RIIA002) |
| Indexed By | SCI |
| If | 6.567 |
| Language | 英语 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/18438 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Yan, Wenjin; Wang, Kairong; Wang R(王锐) |
| Affiliation | 1.Lanzhou Univ, Sch Basic Med Sci, Dept Pharmacol, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Ma, Mingxia,Zhu, Yuanyuan,Sun, Quantao,et al. The asymmetric synthesis of CF3-containing spiro[pyrrolidin-3,2 '-oxindole] through the organocatalytic 1,3-dipolar cycloaddition reaction[J]. Chemical Communications,2015,51(42):8789-8792. |
| APA | Ma, Mingxia.,Zhu, Yuanyuan.,Sun, Quantao.,Li, Xiaoyuan.,Su, Jinhuan.,...&王锐.(2015).The asymmetric synthesis of CF3-containing spiro[pyrrolidin-3,2 '-oxindole] through the organocatalytic 1,3-dipolar cycloaddition reaction.Chemical Communications,51(42),8789-8792. |
| MLA | Ma, Mingxia,et al."The asymmetric synthesis of CF3-containing spiro[pyrrolidin-3,2 '-oxindole] through the organocatalytic 1,3-dipolar cycloaddition reaction".Chemical Communications 51.42(2015):8789-8792. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| c4cc10216a.pdf（1527KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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