| Chiral separation by counter-current chromatography | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Huang XY(黄新异) ; Di DL(邸多隆); Di DL(邸多隆)
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| 2015 | |
| Source Publication | Trends in Analytical Chemistry
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| ISSN | 0165-9936 |
| Volume | 67Pages:128-133 |
| Abstract | Counter-current chromatography (CCC) is a new, efficient, productive chromatographic technique based on continuous liquid-liquid partition. Recently, it attracted more attention in chiral separation due to its high load capacity, cheap liquid stationary phase and low solvent consumption, when compared to traditional chiral separation techniques. This review presents advances and applications of chiral separation using high-speed CCC in recent years. We summarize the major benefits and the limitations of chiral separation by CCC. We introduce in detail some novel methods, which can improve the resolution of enantiomers and are easily achieved on classical CCC apparatus. We also outline challenges and future perspectives in developing chiral separation by CCC. |
| Keyword | Biphasic Chiral Recognition Chiral Chromatography Chiral Selector Chiral Separation Counter-current Chromatography Liquid-liquid Partition Multiple Dual-mode Elution Recycling Elution Mode Separation Efficiency Solvent System |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1016/j.trac.2015.01.009 |
| Funding Organization | the National Natural Science Foundation of China (NSFC Nos. 20775083;21175142);CAS;the Advanced Bioprocessing Centre at Brunel University, UK |
| Indexed By | SCI |
| If | 7.487 |
| Language | 英语 |
| Funding Project | 药物工艺标准研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/18351 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Di DL(邸多隆) |
| Affiliation | Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 73000, China |
| Recommended Citation GB/T 7714 | Huang XY,Di DL,Di DL. Chiral separation by counter-current chromatography[J]. Trends in Analytical Chemistry,2015,67:128-133. |
| APA | Huang XY,Di DL,&邸多隆.(2015).Chiral separation by counter-current chromatography.Trends in Analytical Chemistry,67,128-133. |
| MLA | Huang XY,et al."Chiral separation by counter-current chromatography".Trends in Analytical Chemistry 67(2015):128-133. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 2015128-133.pdf（627KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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