Evaluation of an efficient and selective adsorbent based on multi-walled carbon nanotubes coated silica microspheres for detecting nucleobases and nucleosides in human urine | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Sun XM(孙小明)1; Tang, Yanan1,2; Di DL(邸多隆)1; Guo M(郭玫)2; Zhao, Lei2; Di DL(邸多隆) | |
2015 | |
Source Publication | New Journal of Chemistry |
ISSN | 1144-0546 |
Volume | 39Issue:7Pages:5513-5521 |
Abstract | Multi-walled carbon nanotubes (MWCNTs) can be used in analytical chemistry for separation and purification and offer the opportunity to determine low concentration compounds in complex systems. Novel multi-walled carbon nanotube coated silica microspheres (MWCNTs/SiO2) were synthesized by the covalent bonding of amino bonds. The characteristics results obtained from emission scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy and Brunauer–Emmett–Teller (BET) surface area analysis showed that MWCNTs/SiO2 was successfully prepared. By evaluating the static adsorption capacities of ten nucleobases and nucleosides, the adsorption capacity of the microspheres for adenine (A), guanine (G), uric acid (UA) and xanthosine (X) was found to be significantly stronger than for others. Moreover, the adsorption capacity depends on the pH value, salinity and contact time. It was shown that π–π conjugation and hydrogen bonding interactions were the two main driving forces for the adsorption of target compounds. Adsorption kinetics and adsorption isotherms showed that the adsorption process was a chemical and multilayer adsorption. They could be determined within the test ranges with a good correlation coefficient (r > 0.997). The limits of detection (LOD) for A, G, UA and X were 1.22, 2.02, 0.32 and 2.28 ng mL−1, respectively. The intra- and inter-day relative standard deviations (RSDs) were no more than 6.5%. This procedure therefore afforded a convenient, sensitive and accurate method with a high extraction efficiency for the determination of A, G, UA and X in human urine. |
Subject Area | 分析化学与药物化学 |
DOI | 10.1039/c4nj01777c |
Funding Organization | the National Natural Science Foundation of China (NSFC No. 21205126);Important Technology Plan Projects of Lanzhou City (2012-2-66) |
Indexed By | SCI |
If | 3.277 |
Language | 英语 |
Funding Project | 药物工艺标准研究组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/18315 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Di DL(邸多隆) |
Affiliation | 1.Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, 18 Tianshui Middle Road, Lanzhou, China 2.Key Laboratory of Chemistry and Quality for Traditional Chinese Medicines of the College of Gansu Province, Department of Pharmacy, Gansu College of Traditional Chinese Medicine, 35 Dingxi East Road, Lanzhou, China |
Recommended Citation GB/T 7714 | Sun XM,Tang, Yanan,Di DL,et al. Evaluation of an efficient and selective adsorbent based on multi-walled carbon nanotubes coated silica microspheres for detecting nucleobases and nucleosides in human urine[J]. New Journal of Chemistry,2015,39(7):5513-5521. |
APA | Sun XM,Tang, Yanan,Di DL,Guo M,Zhao, Lei,&邸多隆.(2015).Evaluation of an efficient and selective adsorbent based on multi-walled carbon nanotubes coated silica microspheres for detecting nucleobases and nucleosides in human urine.New Journal of Chemistry,39(7),5513-5521. |
MLA | Sun XM,et al."Evaluation of an efficient and selective adsorbent based on multi-walled carbon nanotubes coated silica microspheres for detecting nucleobases and nucleosides in human urine".New Journal of Chemistry 39.7(2015):5513-5521. |
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