| Cytotoxic, cell apoptosis and DNA binding properties of some ternary Cu(II) complexes with a reduced Schiff base ligand and heterocyclic bases | |
| Department | 固体润滑国家重点实验室 |
Jia L(贾磊)1,2; Cai, Hong-xin1; Xu, Jun1; Zhou, Heng3; Wu, Wei-na1; Li, Fei-fei1; Wang, Yuan1; Pei XW(裴小维)2 ; Wang, Qin3; Jia L(贾磊)
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| 2013 | |
| Source Publication | Inorganic Chemistry Communications
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| ISSN | 1387-7003 |
| Volume | 35Pages:16-18 |
| Abstract | Three mononuclear mixed ligand Cu(II) complexes of the type [Cu(L)(DTHA)]H2O center dot CH3OH, where H2DTHA is 2-(3,5-di-tert-butyl-2-hydroxybenzylamino) acetic acid and the co-ligand L is 1,10-phenanthroline (phen, 1), dipyrido[3,2-d:2',3'-f]quinoxaline (dpq, 2) dipyrido [3,2-a:2',3'-c]phenazine (dppz, 3) have been isolated and characterized. Absorption and emission spectral studies and viscosity measurements indicated that 3 interacts with DNA more strongly than all of the other complexes through intercalation mode. Furthermore, cytotoxicity studies on the tested four cell line indicated that they can efficiently inhibit the cell proliferation in a time-dependent manner, and the Hoechst 33258 staining assays have also been employed in finding the extent of DNA damage. |
| Keyword | Cell Apoptosis Cytotoxicity Dna Binding Properties Reduce Schiff Base Hoechst 33258 Ternary Cu(Ii) Complexes |
| Subject Area | 材料科学与物理化学 |
| DOI | 10.1016/j.inoche.2013.04.030 |
| Indexed By | SCI |
| If | 2.062 |
| Language | 英语 |
| Funding Project | 材料表面与界面行为研究组 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/18098 |
| Collection | 固体润滑国家重点实验室（LSL） |
| Corresponding Author | Wang, Qin; Jia L(贾磊) |
| Affiliation | 1.Henan Polytech Univ, Dept Chem & Phys, Jiaozuo 454000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China 3.Lanzhou Univ, Sch Life Sci, Inst Canc Biol & Drug Screening, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Jia L,Cai, Hong-xin,Xu, Jun,et al. Cytotoxic, cell apoptosis and DNA binding properties of some ternary Cu(II) complexes with a reduced Schiff base ligand and heterocyclic bases[J]. Inorganic Chemistry Communications,2013,35:16-18. |
| APA | Jia L.,Cai, Hong-xin.,Xu, Jun.,Zhou, Heng.,Wu, Wei-na.,...&贾磊.(2013).Cytotoxic, cell apoptosis and DNA binding properties of some ternary Cu(II) complexes with a reduced Schiff base ligand and heterocyclic bases.Inorganic Chemistry Communications,35,16-18. |
| MLA | Jia L,et al."Cytotoxic, cell apoptosis and DNA binding properties of some ternary Cu(II) complexes with a reduced Schiff base ligand and heterocyclic bases".Inorganic Chemistry Communications 35(2013):16-18. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| LZ01027586.pdf（469KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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