Preparation and characterization of a novel  pH sensitive chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate composite hydrogel bead for controlled release of diclofenac sodium

	Preparation and characterization of a novel pH sensitive chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate composite hydrogel bead for controlled release of diclofenac sodium
Department	环境材料与生态化学研究发展中心
	Wang Q(汪琴); Zhang JP(张俊平); Wang AQ(王爱勤); 王爱勤 aqwang@licp.cas.cn
	2009
Source Publication	Carbohydrate Polymers
ISSN	0144-8617
Volume	78 Issue:4 Pages:731-737
Abstract	A series of pH-sensitive composite hydrogel beads composed of chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate (CTS-g-PAA/APT/SA) was prepared as drug delivery matrices crosslinked by Ca2+ owing to the ionic gelation of SA. The structure and surface morphology of the composite hydrogel beads were characterized by FTIR and SEM, respectively. pH-sensitivity of these composite hydrogels beads and the release behaviors of drug from them were investigated. The results showed that the composite hydrogel beads had good pH-sensitivity. The cumulative release ratios of diclofenac sodium (DS) from the composite hydrogel beads were 3.76% in pH 2.1 solution and 100% in pH 6.8 solutions within 24 h, respectively. However, the cumulative release ratio of DS in pH 7.4 solution reached 100% within 2 h. The DS cumulative release ratio reduced with increasing APT content from 0 to 50 wt%. The drug release was swelling-controlled at pH 6.8.
Keyword	Composite Hydrogel Bead Ph-sensitive Controlled Release Diclofenac Sodium
Subject Area	药物释放
Funding Organization	中科院西部行动项目(KGCX2-YW-501)
Indexed By	SCI
Language	英语
Funding Project	功能复合材料组
Document Type	期刊论文
Identifier	http://ir.licp.cn/handle/362003/161
Collection	环境材料与生态化学研究发展中心
Corresponding Author	王爱勤 aqwang@licp.cas.cn
Recommended Citation GB/T 7714	Wang Q,Zhang JP,Wang AQ,et al. Preparation and characterization of a novel pH sensitive chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate composite hydrogel bead for controlled release of diclofenac sodium[J]. Carbohydrate Polymers,2009,78(4):731-737.
APA	汪琴,张俊平,王爱勤,&王爱勤 aqwang@licp.cas.cn.(2009).Preparation and characterization of a novel pH sensitive chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate composite hydrogel bead for controlled release of diclofenac sodium.Carbohydrate Polymers,78(4),731-737.
MLA	汪琴,et al."Preparation and characterization of a novel pH sensitive chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate composite hydrogel bead for controlled release of diclofenac sodium".Carbohydrate Polymers 78.4(2009):731-737.

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