| Effect of Occupational Manganese Exposure on Uric Acid Levels in Human Urine | |
| Department | 甘肃省天然药物重点实验室 |
Sun XM(孙小明) ; Liu YW(刘晔玮); Wang ZQ(王振全); Li HB(李红兵); Liu Y(刘芸); Di DL(邸多隆)
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| 2011 | |
| Source Publication | Biomedical and Environmental Sciences
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| ISSN | 0895-3988 |
| Volume | 24Issue:3Pages:222-227 |
| Abstract | Objective To investigate the effect of long‐term and low‐level occupational Mn exposure on the levelof uric acid (UA) in human urine.Methods In this study, 65 volunteers were recruited, who were working on welding and foundry work in an plant in Gansu province, China. Additionally, 29 control samples were collected from individuals who did not have any history of excessive Mn exposure. An improved high performance liquid chromatography system equipped with a diode‐array detector (HPLC‐DAD) method was developed to determine the UA level in human urine. A Spectra AA 220 Atomic Absorption Spectrophotometer (AAS) was used to measure the Mn level in the urine.Results The analytical method was validated for concentrations ranging from 3.82–45.84 μg/mL with acceptable accuracy, precision, and recovery. Overall, the UA levels of Mn exposure samples were significantly lower than that of control samples (P<0.05). Conclusion The practical method developed here is suitable for both routine monitoring of UA level in human urine and metabolism research. Long‐term and low‐level occupational Mn exposure may lead to a lower UA level in urine, and UA might be an indicator of the early stage of manganism. |
| Keyword | High‐performance Liquid Chromatography Uric Acid Occupational Mn Exposure |
| Subject Area | 分析化学与药物化学 |
| Funding Organization | the Hundred Talents Program of the Chinese Academy of Sciences (CAS) in 2007;the National Natural Sciences Foundation of China (NSFC No.20775083) |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 药物工艺标准研究组 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/1552 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Di DL(邸多隆) |
| Recommended Citation GB/T 7714 | Sun XM,Liu YW,Wang ZQ,et al. Effect of Occupational Manganese Exposure on Uric Acid Levels in Human Urine[J]. Biomedical and Environmental Sciences,2011,24(3):222-227. |
| APA | 孙小明,刘晔玮,王振全,李红兵,刘芸,&邸多隆.(2011).Effect of Occupational Manganese Exposure on Uric Acid Levels in Human Urine.Biomedical and Environmental Sciences,24(3),222-227. |
| MLA | 孙小明,et al."Effect of Occupational Manganese Exposure on Uric Acid Levels in Human Urine".Biomedical and Environmental Sciences 24.3(2011):222-227. |
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