| Investigation of Enantiomer Separation by LC with a New Bonded Cellulose 3,5-Dimethylphenylcarbamate Chiral Stationary Phase | |
| Department | 甘肃省天然药物重点实验室 |
Ming YF(明永飞); Zhao L(赵亮) ; Zhang HL(张红丽); Shi YP(师彦平); Li YM(李永民)
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| 2006 | |
| Source Publication | Chromatographia
 |
| ISSN | 0009-5893 |
| Volume | 64Issue:5/6Pages:273-280 |
| Abstract | A chiral stationary phase has been prepared from the 3,5-dimethylphenylcarbamate of cellulose chemically bonded to 3-aminopropylsilica gel at the 6-positions of the glucose units. The phase has been used to study direct liquid chromatographic enantioselective separation of five racemates. The effects on resolution of modifiers (alcohols, THF, and chloroform), flow rate, and temperature were investigated. It was found that the concentration and structure of the alcohol modifier can affect the separation; enantiomer separations were improved to different extents by addition of THF or chloroform to the mobile phase. Flow rate and temperature can also effect the resolution of racemates. In the range 10–40 C there was a linear relationship between ln k (or ln a) and 1/T (r > 0.98) for four of the compounds. These results indicate retention mechanism does not change as a function of temperature. |
| Keyword | Column Liquid Chromatograph Enantiomer Separation Bonded Cellulose 3 5-dimethylphenylcarbamate |
| Subject Area | 分析化学与药物化学 |
| Funding Organization | the National Natural Science Foundation of China (No. 20375045);the Province Natural Science Foundation of Gansu (No. 3ZS041-A25-23);the Light in China’s Western Region (2003) |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 药物手性分离研究组 ; 药物化学成分研究组 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/1492 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Li YM(李永民) |
| Recommended Citation GB/T 7714 | Ming YF,Zhao L,Zhang HL,et al. Investigation of Enantiomer Separation by LC with a New Bonded Cellulose 3,5-Dimethylphenylcarbamate Chiral Stationary Phase[J]. Chromatographia,2006,64(5/6):273-280. |
| APA | 明永飞,赵亮,张红丽,师彦平,&李永民.(2006).Investigation of Enantiomer Separation by LC with a New Bonded Cellulose 3,5-Dimethylphenylcarbamate Chiral Stationary Phase.Chromatographia,64(5/6),273-280. |
| MLA | 明永飞,et al."Investigation of Enantiomer Separation by LC with a New Bonded Cellulose 3,5-Dimethylphenylcarbamate Chiral Stationary Phase".Chromatographia 64.5/6(2006):273-280. |
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| Investigation of Ena（395KB） | 开放获取 | License | View Application Full Text | |||
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