| Preparation and swelling properties of pH sensitive composite hydrogel beads based on chitosan-g-poly (acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release | |
| Department | 环境材料与生态化学研究发展中心 |
Wang Q(汪琴) ; Xie XL(谢小玲); Zhang XW(张小伟); Zhang JP(张俊平); Wang AQ(王爱勤); 王爱勤 aqwang@licp.cas.cn
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| 2010 | |
| Source Publication | International Journal of Biological Macromolecules
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| ISSN | 0141-8130 |
| Volume | 46Issue:3Pages:356-362 |
| Abstract | A series of pH-sensitive composite hydrogel beads, chitosan-g-poly (acrylic acid)/vermiculite/sodium alginate (CTS-g-PAA/VMT/SA), was prepared using CTS-g-PAA/VMT composite and SA by Ca2+ as the crosslinking agent. The structure and morphologies of the developed composite hydrogel beads were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy. The swelling properties and pH-sensitivity of the beads were investigated. In addition, the drug loading and controlled release behaviors of the beads were also evaluated using diclofenac sodium (DS) as the model drug in stimulated gastric fluids (pH 2.1) and intestinal fluids (pH 6.8). The results indicate that the composite hydrogel beads showed good pH-sensitivity. The release rate of the drug from the composite hydrogel beads is remarkably slowed down, which indicated that incorporating VMT into the composite hydrogel beads can improve the burst release effect of the drug. |
| Keyword | Composite Hydrogel Bead Vermiculite Ph-sensitive Controlled Release |
| Subject Area | 药物释放 |
| Funding Organization | 中科院院长奖获得者科研启动专项(2008-06) |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 功能复合材料组 |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/137 |
| Collection | 环境材料与生态化学研究发展中心 |
| Corresponding Author | 王爱勤 aqwang@licp.cas.cn |
| Recommended Citation GB/T 7714 | Wang Q,Xie XL,Zhang XW,et al. Preparation and swelling properties of pH sensitive composite hydrogel beads based on chitosan-g-poly (acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release[J]. International Journal of Biological Macromolecules,2010,46(3):356-362. |
| APA | 汪琴,谢小玲,张小伟,张俊平,王爱勤,&王爱勤 aqwang@licp.cas.cn.(2010).Preparation and swelling properties of pH sensitive composite hydrogel beads based on chitosan-g-poly (acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release.International Journal of Biological Macromolecules,46(3),356-362. |
| MLA | 汪琴,et al."Preparation and swelling properties of pH sensitive composite hydrogel beads based on chitosan-g-poly (acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release".International Journal of Biological Macromolecules 46.3(2010):356-362. |
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| 2010463356362.pdf（856KB） | 开放获取 | License | View Application Full Text | |||
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