| pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium | |
| Department | 环境材料与生态化学研究发展中心 |
Hua SB(华水波); Ma HZ(马海珍); Li X(李迅); Yang HX(杨会霞); Wang AQ(王爱勤) ; 王爱勤 aqwang@licp.cas.cn
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| 2010 | |
| Source Publication | International Journal of Biological Macromolecules
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| ISSN | 0141-8130 |
| Volume | 46Issue:5Pages:517-523 |
| Abstract | In order to enhance the drug entrapment efficiency and improve the swelling behaviors of drug delivery system, Ca2+ crosslinking and freeze-thawing (FT) cycle techniques were used to prepare sodium alginate/poly(vinyl alcohol) (SA/PVA) hydrogel beads. The mixture solution of SA and PVA was firstly crosslinked with Ca2+ to form beads and then subjected to freezing–thawing cycles for further crosslinking. The crosslinking process was confirmed by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The swelling and pH-sensitive properties of the beads were investigated, and the drug loading and controlled release properties of the beads were also evaluated using diclofenac sodium as the model drug. Results indicate that the bead was formed well and the encapsulation efficiency was greatly improved when the ratio of PVA to SA is 3:1. The swelling and degradation of the developed beads was influenced by pH of the test medium and PVA content. FT process enhanced drug entrapment efficiency, improved swelling behaviors and slowed release of drug from the dual crosslinked beads compared with pure SA beads crosslinked with Ca2+ ion alone, which provide a facile and effective method to improve the drug delivery system. |
| Keyword | Alginate Poly(Vinyl Alcohol) Freezing–thawing Swelling Release |
| Subject Area | 药物释放 |
| Funding Organization | 中科院院长奖获得者科研启动专项(2008-06) |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 功能复合材料组 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/129 |
| Collection | 环境材料与生态化学研究发展中心 |
| Corresponding Author | 王爱勤 aqwang@licp.cas.cn |
| Recommended Citation GB/T 7714 | Hua SB,Ma HZ,Li X,et al. pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium[J]. International Journal of Biological Macromolecules,2010,46(5):517-523. |
| APA | 华水波,马海珍,李迅,杨会霞,王爱勤,&王爱勤 aqwang@licp.cas.cn.(2010).pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium.International Journal of Biological Macromolecules,46(5),517-523. |
| MLA | 华水波,et al."pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium".International Journal of Biological Macromolecules 46.5(2010):517-523. |
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| 2010465517523.pdf（775KB） | 开放获取 | License | View Application Full Text | |||
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