| Selective determination of L-dopa in the presence of uric acid and ascorbic acid at a gold nanoparticle self-assembled carbon nanotube-modified pyrolytic graphite electrode | |
| Department | 甘肃省天然药物重点实验室 ; OSSO国家重点实验室 |
Hu GZ(胡广志); Chen L(陈龙); Guo Y(郭勇) ; Wang XL(王晓来); Shao SJ(邵士俊)
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| 2010 | |
| Source Publication | Electrochimica Acta
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| ISSN | 0013-4686 |
| Volume | 55Pages:4711-4716 |
| Abstract | Gold nanoparticle-functionalized carbon nanotubes (AuNP-CNT) have been prepared by a novel selfassembly method. The new material has been characterized by transmission electron microscopy (TEM) and X-ray diffraction (XRD) and utilized for constructing AuNP-CNT-modified pyrolytic graphite electrode (AuNP-CNT/PGE) to investigate the electrochemical behavior of L-dopa in neutral phosphate buffer solution. Compared to bare PG electrode, AuNP-CNT/PGE shows novel properties towards the electrochemical redox of L-dopa in phosphate buffer solution at pH 7.0. The oxidation potential of L-dopa shows a significant decrease at the AuNP-CNT/PGE. The oxidation current of L-dopa is about 5-fold higher than that of the unmodified PGE. Using differential pulse voltammetry (DPV) method, the oxidation current is well linear with L-dopa concentration in the range of 0.1–150_M, with a detection limit of about 50nM (S/N = 3). The proposed electrode can also effectively avoid the interference of ascorbic acid and uric acid, making the proposed sensor suitable for the accurate determination of L-dopa in both pharmaceutical preparations and human body fluids. |
| Keyword | Gold Nanoparticles Carbon Nanotubes Self-assembly L-dopa Pyrolytic Graphite Electrode |
| Subject Area | 分析化学与药物化学 |
| Funding Organization | National Natural Science Foundation of China (No. 20672121);the open fund of State Key Laboratory of Oxo Synthesis & Selective Oxidation (Grant No.OSSO2008kjk6) |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 药物分子识别研究组 ; 多相选择氧化研究组 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/1214 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Wang XL(王晓来); Shao SJ(邵士俊) |
| Recommended Citation GB/T 7714 | Hu GZ,Chen L,Guo Y,et al. Selective determination of L-dopa in the presence of uric acid and ascorbic acid at a gold nanoparticle self-assembled carbon nanotube-modified pyrolytic graphite electrode[J]. Electrochimica Acta,2010,55:4711-4716. |
| APA | 胡广志,陈龙,郭勇,王晓来,&邵士俊.(2010).Selective determination of L-dopa in the presence of uric acid and ascorbic acid at a gold nanoparticle self-assembled carbon nanotube-modified pyrolytic graphite electrode.Electrochimica Acta,55,4711-4716. |
| MLA | 胡广志,et al."Selective determination of L-dopa in the presence of uric acid and ascorbic acid at a gold nanoparticle self-assembled carbon nanotube-modified pyrolytic graphite electrode".Electrochimica Acta 55(2010):4711-4716. |
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